Director - PKDM - Small Molecule Portfolio Strategy & Leadership
Amgen
August 09, 2026
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development
Director - PKDM - Small Molecule Portfolio Strategy & Leadership
What You Will Do
Serve as a strategic PKDM-BA leader on cross-functional teams, advancing small molecule programs from candidate discovery through clinical development and regulatory submission; influence portfolio strategy and critical development decisions.
Key Responsibilities
- Provide strategic PKDM-BA leadership for small molecule discovery and development programs.
- Drive cross-functional project team progression via scientific innovation, risk assessment, and proactive problem solving.
- Lead PKDM-BA contributions to regulatory submissions (INDs, NDAs) and interactions with global health authorities.
- Define and execute scientific strategies for candidate selection, optimization, development, and registration of small molecule therapeutics.
- Identify and implement emerging technologies/approaches to improve understanding of drug disposition and development outcomes.
- Partner with business development for external opportunity assessment and scientific due diligence.
- Build collaborative relationships across therapeutic areas and partner functions.
- Recruit, develop, mentor, and inspire scientific talent.
- Contribute to organizational strategy for future small molecule PKDM-BA capabilities.
Basic Qualifications (required)
- PhD (Doctorate)
OR PharmD
OR MD (with relevant post-doc where applicable) + 5 years industry experience in relevant disciplines
OR Master’s + 8 years industry experience
OR Bachelor’s + 10 years industry experience
Preferred Qualifications
- Leadership across multiple small molecule programs.
- Regulatory submission experience (INDs/NDAs).
- Expertise in drug disposition, PK, and translational strategies.
- People management; publications/presentations; strong communication and stakeholder influence.
Benefits (explicitly stated)
- Total Rewards Plan; employee benefits package including retirement/savings contributions, medical/dental/vision, life/disability, flexible spending; annual bonus/incentive; stock-based long-term incentives; time-off; flexible work models where possible.
Application Instructions
- Apply via careers.amgen.com; no application deadline—applications accepted until sufficient number or selection.
What You Will Do
Serve as a strategic PKDM-BA leader on cross-functional teams, advancing small molecule programs from candidate discovery through clinical development and regulatory submission; influence portfolio strategy and critical development decisions.
Key Responsibilities
- Provide strategic PKDM-BA leadership for small molecule discovery and development programs.
- Drive cross-functional project team progression via scientific innovation, risk assessment, and proactive problem solving.
- Lead PKDM-BA contributions to regulatory submissions (INDs, NDAs) and interactions with global health authorities.
- Define and execute scientific strategies for candidate selection, optimization, development, and registration of small molecule therapeutics.
- Identify and implement emerging technologies/approaches to improve understanding of drug disposition and development outcomes.
- Partner with business development for external opportunity assessment and scientific due diligence.
- Build collaborative relationships across therapeutic areas and partner functions.
- Recruit, develop, mentor, and inspire scientific talent.
- Contribute to organizational strategy for future small molecule PKDM-BA capabilities.
Basic Qualifications (required)
- PhD (Doctorate)
OR PharmD
OR MD (with relevant post-doc where applicable) + 5 years industry experience in relevant disciplines
OR Master’s + 8 years industry experience
OR Bachelor’s + 10 years industry experience
Preferred Qualifications
- Leadership across multiple small molecule programs.
- Regulatory submission experience (INDs/NDAs).
- Expertise in drug disposition, PK, and translational strategies.
- People management; publications/presentations; strong communication and stakeholder influence.
Benefits (explicitly stated)
- Total Rewards Plan; employee benefits package including retirement/savings contributions, medical/dental/vision, life/disability, flexible spending; annual bonus/incentive; stock-based long-term incentives; time-off; flexible work models where possible.
Application Instructions
- Apply via careers.amgen.com; no application deadline—applications accepted until sufficient number or selection.