Director, Pharmacometrics & Clinical Pharmacology

Role: Senior leadership position as Director of Pharmacometrics and Clinical Pharmacology, overseeing quantitative strategies across Arrowhead's RNAi therapeutic pipeline. Responsibilities: lead model-informed drug development including PK/PD modeling, exposure-response analyses, dose optimization, and translational modeling for global clinical programs; support first-in-human studies, dose escalation, proof-of-concept, DDI, food effect, and special population assessments; contribute to regulatory submissions and interactions, authoring key documents; collaborate with cross-functional teams in Clinical Development, Regulatory, Biometrics, and Medical Affairs; stay current with scientific and regulatory advances. Requirements: PhD or equivalent in Pharmacokinetics, Pharmacology, Biomedical Engineering, or related field; 12+ years in pharmacometrics/clinical pharmacology supporting late-stage development and regulatory filings; expertise in population PK/PD modeling, proficiency in NONMEM; strong knowledge of exposure-response, translational modeling, and model-informed drug development; experience with regulatory agencies including FDA and EMA; familiarity with PBPK, QSP, and biologic modalities preferred. High-Value: RNAi therapeutics, gene silencing, late-stage development, global regulatory engagement, complex biologics, model-informed drug development. Work setup: not specified; salary range varies by location (~$200K-$255K USD).