Director, Pharmacometrics & Clinical Pharmacology

Role: Senior scientific leader in pharmacometrics and clinical pharmacology for Arrowhead's RNAi therapeutics portfolio, supporting global development and regulatory filings. Responsibilities: oversee model-informed drug development including PK/PD modeling, exposure-response, dose optimization, and translational analyses; contribute to first-in-human studies, dose escalation, drug-drug interaction, and special population evaluations; lead internal and external PK/PD analyses, author regulatory documents, and support IND/CTA/NDA submissions; collaborate with cross-functional teams in Clinical Development, Regulatory, Biometrics, and Medical Affairs; present data and strategies to senior management; stay current with scientific and regulatory advances in pharmacometrics and RNAi modalities. Requirements: PhD or equivalent in Pharmacokinetics, Pharmacology, or related field; 12+ years experience in pharmacometrics/clinical pharmacology supporting late-stage development and global submissions; expertise in population PK/PD modeling using software like NONMEM; strong understanding of exposure-response, translational modeling, and model-informed drug development; experience with regulatory interactions; knowledge of PBPK, QSP, or systems pharmacology is preferred; experience with oligonucleotide, RNAi, or biologic therapeutics advantageous. Preferred: familiarity with PBPK/QSP modeling; work setup includes collaboration with internal teams and CROs. Location: flexible with competitive salary range, based in Wisconsin or California.