Director, Pharmacometrics & Clinical Pharmacology

Role: Senior leadership position as Director of Pharmacometrics and Clinical Pharmacology, guiding strategic and scientific aspects of Arrowhead's RNAi therapeutic development. Responsibilities: oversee pharmacometric modeling, clinical pharmacology strategies for first-in-human, dose optimization, and regulatory submissions; lead PK/PD analyses, contribute to INDs and NDA/BLA documents; collaborate with cross-functional teams including Clinical Development, Regulatory, and Biometrics; present analyses and maintain knowledge of industry trends. Requirements: PhD in Pharmacokinetics, Pharmacology, or related field; 12+ years in pharmacometrics/clinical pharmacology supporting late-stage programs and global regulatory filings; expertise in population PK/PD modeling (e.g., NONMEM), exposure-response, translational modeling; experience with RNAi or biologics preferred. HighValue: Focus on RNAi therapeutics, regulatory interactions (FDA, EMA), model-informed drug development, late-stage development, and biologic modalities. WorkSetup: not specified, but likely office-based in California or Wisconsin with extensive cross-functional collaboration.