Director, Operations

Director, Operations

Company: Nautilus Biotechnology

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

We are hiring for a Director, Operations to join our growing team. This role is a critical leadership position responsible for ensuring Nautilus's Instrument and Flow Cell Operations meet commercialization timelines and compliance standards. As a leader in this position, you will translate the company's strategy into clear operational roadmaps and act as a trusted advisor to the executive team. You will have the opportunity to build and manage high-performing teams and contribute to a mission-driven culture as you help us bring our platform to the world.

Responsibilities

• Develop and execute operational strategies aligned with company objectives.
• Manage timelines and deliverables for product development and commercialization.
• Oversee the production of flowcells and instruments.
• Manage the supply chain and logistics, including sourcing, inventory, and distribution of materials and products. You'll also be responsible for architecting complex supply chains with multiple partners.
• Ensure operations comply with FDA, GMP, ISO, and other relevant regulatory standards.
• Control operational budgets and resource allocation.
• Collaborate with cross-functional teams, including R&D, QA/QC, and commercial teams, to drive results.
• Implement and optimize systems for quality assurance and control.
• Lead process improvement initiatives to enhance efficiency and scalability.
• Build and manage teams across manufacturing, supply chain, and logistics, fostering a culture of accountability and innovation.
• Report on operational performance metrics to senior management and adjust tactics as needed.
• Lead teams through periods of rapid growth, transformation, and scaling with clarity and confidence.

Qualifications

• Education: Bachelor’s or Master’s in Life Sciences, Engineering, or Business is required; an MBA is often preferred.
• Experience: 6-10 years of experience working in Biotech, Pharmaceutical Operations, or Medical Device companies, including leadership roles.
• Skills: Strong knowledge of GMP/GxP compliance and regulatory landscapes is required.

Preferred Qualifications

• Experience in Lean Manufacturing and Six Sigma.
• Experience implementing ERP, MES, or Advanced Planning Solutions.
• Experience with semiconductor manufacturing and packaging processes.
• Experience with a product introduction that achieved 510K compliance.
• Experience leading operations at a company that scaled to over $500M.

Nautilus Team Culture

• We are determined to do whatever it takes to get our platform into the hands of researchers who will use it to upend the status quo in basic research and healthcare.
• We work on cross functional teams, wear many hats, take risks to work through uncertainty, enjoy working collaboratively on challenging problems, and celebrate one another’s victories.
• We go above and beyond, but also strive to provide a supportive atmosphere of colleagues who are willing to lend a helping hand and make working at Nautilus not only fulfilling in its end goals, but enjoyable on a day-to-day basis.

Compensation Range: $189K - $252K