Director, Oncology Translational Research

Role Summary

Director, Oncology Translational Research is a key scientific leader on the Oncology Translational Research global leadership team, accountable for generating and integrating genomic, transcriptomic, and proteomic data to deepen our understanding of cancer biology and guide the development of multiple therapeutic modalities (low molecular weight molecules, radioligand therapies, biologics, CAR-T). The role leads both forward and reverse translational research for preclinical and clinical oncology programs, including exploratory clinical biomarker development of high-plex molecular assays. Located in Cambridge, MA (remote work not available); travel up to 10% may be required.

Responsibilities

• Directs successful translation of pre-clinical research to human clinical trials, leveraging learnings from genomic, transcriptomic, and proteomic analyses of both preclinical models and patient samples.
• Guides exploratory biomarker plan design and strategy for early-stage Translational Clinical Oncology (TCO) and Global Drug Development (GDD) trials, serving as a core member of the Biomarker Review Committee.
• Integrates pre-clinical and emerging clinical efficacy and biomarker data to understand cancer biology and mechanisms of response and resistance to therapy in patients.
• Leverages quantitative/computational background to collaborate effectively with Oncology Data Science to analyze high-dimensional preclinical and clinical data to guide clinical decisions and inform research strategy.
• Explores and onboards innovative technologies to advance translational research and new biomarker development.
• Responsible for quality and compliance of exploratory molecular biomarker assays.
• Interfaces closely with late-stage clinical development to enable translational research and development of regulated biomarker assays.
• Leads a team responsible for driving genomic, transcriptomic, and proteomic preclinical and clinical data creation, enabling AI/ML modeling, and generating actionable insights.
• Develops talent by being a mentor, coach, and educational resource.
• Member of the Oncology Translational Research global leadership team and responsible for representing leadership at senior levels/disease boards and other internal/external forums.

Qualifications

• Required: M.D., Ph.D. or comparable doctoral degree in a relevant discipline.
• Required: 6+ years of experience in a pharmaceutical or biotech-based company or as a leader in academia ideally with multiple years in a matrixed leadership role.
• Required: Outstanding scientific depth and breadth with a demonstrated track record of high-impact publications in the field of oncology and/or molecular pathology.
• Required: Strong leadership presence and the ability to develop talent; demonstrated ability to lead and influence.
• Required: Experience working with senior leaders (unit heads, board members), while equally comfortable collaborating with junior associates.
• Required: Excellent analytical and communication skills.
• Required: Must have a strong quantitative/computational background and broad scientific/technical knowledge base in the area of oncology, including a solid track record of innovation.
• Preferred: Demonstrated leadership and a strong track record of accomplishments within the fields of oncology and molecular pathology (>6 years).
• Preferred: Completion of a Molecular Genetic Pathology fellowship with board certification from the American Board of Pathology or American Board of Medical Genetics and Genomics.