Director - Oligonucleotide Chemistry

Role: Lead the oligonucleotide synthesis scale-up team within Lilly's Genetic Medicines division, focusing on RNAi therapeutic candidates from preclinical to clinical stages. Responsibilities include managing team operations, implementing synthesis methodologies, collaborating with discovery and CMC teams for material planning, troubleshooting, and innovating new synthesis technologies. The role requires guiding cross-functional communication to ensure timely delivery of critical materials and overseeing budget for instrumentation upgrades. Qualifications: PhD in Chemistry, Biochemistry, or related field with 5+ years of oligonucleotide synthesis experience, preferably in solid-phase synthesis. Skills include expertise in synthetic organic and nucleic acid chemistry, troubleshooting and optimizing synthesis protocols, chromatography, and conjugation strategies for delivery. Preferred experience involves team supervision, analytical instrumentation (e.g., LC-MS, UPLC), and development of novel conjugates. High-value biopharma specifics: focus on RNAi modalities, large-scale oligonucleotide production, and advancing therapeutics for impactful patient therapies. Work setup: Not explicitly stated, but likely in a collaborative, fast-paced environment; travel details not specified.