Director - Oligonucleotide Analytical Chemistry
Eli Lilly and Company
2 months ago
On-site
Indianapolis, IN
$148,500 - $257,400 USD yearly
Clinical Research and Development
Responsibilities:
- Provide technical leadership for Lilly Genetic Medicine (LGM) analytical activities, including analytical characterization, biophysical characterization, downstream processing method development, open-access QC workflows, analytical IT, and analytical instrumentation and operation readiness; ensure methods are technically sound, well developed, and fit-for-purpose.
- Partner with the Early Phase Development team and the drug discovery team to define and deliver analytical data packages supporting molecules moving from discovery to development.
- Mentor and develop the scientific team; support continued technical and professional growth, and encourage excellence and knowledge sharing.
- Plan and manage short- and long-term analytical investments; develop/review technical agendas and timelines; recommend resource allocation; communicate progress and propose changes to timeline, objectives, or direction.
- Demonstrate high learning agility across novel drug modalities, including oligonucleotides, antibody-oligonucleotide conjugates, and peptide-oligonucleotide conjugates.
- Manage collaborative partnerships with external and internal analytical vendors to supplement LGM analytical resources.
Basic Qualifications:
- Ph.D. in analytical chemistry, bioanalytical chemistry, or related field with 7+ years of biopharmaceutical sector experience following graduation.
- 2+ years of experience in people management and analytical laboratory operations.
Additional Skills/Preferences:
- Experience leading analytical efforts in pharmaceutical product discovery and/or development, including developing and validating analytical methods.
- Experience with technical transfer of analytical methods from discovery to development.
- Expertise in separation sciences for oligonucleotides (RP, HILIC, HIC, IEX, SEC, CE).
- Experience with scale-up sample preparation and analytical characterization of oligonucleotides and/or antibody-oligonucleotide/peptide-oligonucleotide conjugates.
- Solid understanding of chemical synthesis, purification, and formulation requirements.
- Proficiency in biophysical/analytical characterization techniques (e.g., light scattering, chromatography, mass spectrometry, backgrounded membrane imaging).
Additional Information:
- Travel: 15–20%.
- Location: On-site, Indianapolis, IN (Lilly Corporate Center).
Benefits (as stated):
- Eligibility for company bonus (full-time equivalent).
- Comprehensive benefit program: 401(k) eligibility, pension, vacation, medical/dental/vision/prescription benefits, flexible benefits (e.g., healthcare and dependent day care FSAs), life insurance and death benefits, certain time off and leave of absence benefits, and well-being benefits (e.g., employee assistance program, fitness benefits, employee clubs/activities).
Compensation (as stated):
- Anticipated base pay: $148,500–$257,400.
- Provide technical leadership for Lilly Genetic Medicine (LGM) analytical activities, including analytical characterization, biophysical characterization, downstream processing method development, open-access QC workflows, analytical IT, and analytical instrumentation and operation readiness; ensure methods are technically sound, well developed, and fit-for-purpose.
- Partner with the Early Phase Development team and the drug discovery team to define and deliver analytical data packages supporting molecules moving from discovery to development.
- Mentor and develop the scientific team; support continued technical and professional growth, and encourage excellence and knowledge sharing.
- Plan and manage short- and long-term analytical investments; develop/review technical agendas and timelines; recommend resource allocation; communicate progress and propose changes to timeline, objectives, or direction.
- Demonstrate high learning agility across novel drug modalities, including oligonucleotides, antibody-oligonucleotide conjugates, and peptide-oligonucleotide conjugates.
- Manage collaborative partnerships with external and internal analytical vendors to supplement LGM analytical resources.
Basic Qualifications:
- Ph.D. in analytical chemistry, bioanalytical chemistry, or related field with 7+ years of biopharmaceutical sector experience following graduation.
- 2+ years of experience in people management and analytical laboratory operations.
Additional Skills/Preferences:
- Experience leading analytical efforts in pharmaceutical product discovery and/or development, including developing and validating analytical methods.
- Experience with technical transfer of analytical methods from discovery to development.
- Expertise in separation sciences for oligonucleotides (RP, HILIC, HIC, IEX, SEC, CE).
- Experience with scale-up sample preparation and analytical characterization of oligonucleotides and/or antibody-oligonucleotide/peptide-oligonucleotide conjugates.
- Solid understanding of chemical synthesis, purification, and formulation requirements.
- Proficiency in biophysical/analytical characterization techniques (e.g., light scattering, chromatography, mass spectrometry, backgrounded membrane imaging).
Additional Information:
- Travel: 15–20%.
- Location: On-site, Indianapolis, IN (Lilly Corporate Center).
Benefits (as stated):
- Eligibility for company bonus (full-time equivalent).
- Comprehensive benefit program: 401(k) eligibility, pension, vacation, medical/dental/vision/prescription benefits, flexible benefits (e.g., healthcare and dependent day care FSAs), life insurance and death benefits, certain time off and leave of absence benefits, and well-being benefits (e.g., employee assistance program, fitness benefits, employee clubs/activities).
Compensation (as stated):
- Anticipated base pay: $148,500–$257,400.