Director of Toxicology

Role: Director of Toxicology leading nonclinical safety strategies for small molecule and antisense oligonucleotide therapies targeting CNS disorders. Responsibilities include designing and overseeing toxicology studies across discovery to IND-enabling phases, evaluating safety data, and contributing to regulatory documents such as INDs, CTAs, and NDA/MAA submissions. The role involves managing external CROs, cross-functional collaboration with Discovery, DMPK, Bioanalysis, Clinical Pharmacology, and Regulatory teams, and providing scientific leadership on safety assessments. Qualifications: PhD or Master's in Toxicology, Pharmacology, or related field; 8+ years of biotech/pharma/CRO experience with deep expertise in nonclinical safety studies, regulatory toxicology, and GxP compliance. Preferred skills include experience in reproductive, genetic toxicology, or safety pharmacology, and prior interactions with FDA or global authorities. High-Value: Focus on CNS disorders with novel small molecules and ASO therapies, regulatory submissions, and nonclinical safety strategy for early- to late-stage development. Work setup is remote with travel flexibility.