Director of Clinical Biomarkers

Company Name: Recursion

Job Overview

Recursion is at the forefront of reimagining drug discovery and development through broadening the funnel of potential targets, using technology and standardization to build connected data. Recursion has a strong and diverse pipeline that spans first-in-class and best-in-class assets across oncology and rare disease.

Role Overview

As Director of Biomarkers, you will serve as the Biomarker lead on clinical program teams and will be responsible for delivering on fit-for-purpose biomarker strategies that include predictive and pharmacodynamic biomarker assays. You will leverage your deep understanding of the scientific, regulatory and operational aspects of biomarkers to implement appropriate measurements that enable clinical decision making, and the development of safe and effective medicines to address unmet medical need.

Key Responsibilities

• Lead the overall biomarker strategy and execution for assigned program(s) in the Recursion portfolio by serving as the clinical biomarker lead on program/study teams.
• Develop plans collaboratively to deliver fit-for-purpose pharmacodynamic, predictive, prognostic and/or other biomarker assays to support decision making in early development.
• Work with discovery teams to support preclinical to clinical transitions of programs and align overall translational and biomarker strategies.
• Partner with various research and clinical teams, including Clinical Operations, Stats, Data Management, Project Leadership, etc., to contribute to biomarker-related aspects of trial design and conduct, study documents (e.g. protocols, study reference manuals, study reports, INDs etc.), trial readouts/endpoints and regulatory interactions.
• Actively manage CROs, vendors, suppliers and other groups for assay development and qualification/validation.
• Oversee the operational aspects of biomarker implementation, including sample logistics, data management, and coordination with internal teams and CROs.
• Stay current with emerging science and innovate with novel technologies and approaches to generate/analyze/apply data and derive insights on mechanisms, indications, combinations and patient selection/stratification.
• Present biomarker findings at key internal and external meetings.

Team and Collaboration

You will join the Development Sciences team, report to the Head of Clinical Biomarkers, and be part of the Clinical Development organization at Recursion. The Development Sciences team supports the transition of projects from discovery into clinical development and beyond, including translational PK/PD modeling, clinical pharmacology, clinical bioanalysis and biomarkers. This is a collaborative group working closely with discovery to ensure the progression of the right molecule at the right dose for the right patient, support IND filings, and ensure appropriate translational strategies for projects in clinical development.

Requirements

• PhD, MD or equivalent with 8+ years biopharmaceutical industry experience.
• Extensive experience in clinical biomarkers/diagnostics and/or translational research.
• Knowledge of regulatory requirements and biomarker assay development and validation.
• Strong understanding of technology platforms and datasets including omics.
• Expertise in oncology, rare disease, immunology/inflammation.
• Strong critical thinking and problem-solving skills.

Location and Compensation

The position can be based at offices in Salt Lake City, New York City, Toronto, London, or Oxford with a hybrid work environment requiring 50% office presence. Relocation support is available. Compensation ranges from $217,200 - $295,900 USD, $203,200 - $249,700 CAD, or £120,400 - £138,700 GBP, with eligibility for annual bonus, equity compensation, and benefits.