Director, Nonclinical Toxicology Operations

Role: Director of Preclinical Safety and Toxicology Operations overseeing nonclinical safety and toxicology activities in early drug discovery and IND-enabling phases. Responsibilities: manage study design, CRO/vendor selection and contract lifecycle; develop and monitor integrated program plans spanning chemistry, DMPK, pharmacology, safety, and regulatory timelines; coordinate cross-functional teams; facilitate study milestones, report review, and regulatory deliverables. Requirements: M.S. or Ph.D. in life sciences; 10+ years biotech/pharma experience with proven program management, CRO/vendor oversight, and IND support; knowledge of small molecule drug discovery, nonclinical safety, GLP, and targeted protein degradation is preferred. Skills: proficiency in project management tools (MS Project, Smartsheet), excellent organizational and communication skills, ability to influence cross-functionally, and comfort with ambiguity. High-value specifics: supports targeted protein degradation programs in oncology or immunology; involved in late lead optimization through IND; based in Brisbane, CA, onsite, with stakeholder engagement across discovery functions.