Director - Molecular Genetics
Caris Life Sciences
August 29, 2026
On-site
Phoenix, AZ
Clinical Research and Development
Position Summary
The Assistant Laboratory Director, Liquid Profiling supports operational, scientific, and regulatory oversight of the Liquid Profiling Laboratory. Assists in development, validation, implementation, and interpretation of advanced molecular/genomic assays used to identify clinically actionable alterations in oncology specimens, including ctDNA and inherited variants relevant to cancer predisposition and pharmacogenomics.
Job Responsibilities
- Ensure quality, compliance, and clinical integrity of high-complexity molecular testing.
- Assist oversight of molecular testing operations in compliance with CAP, CLIA, NYS DOH, ISO 15189, and other regulations.
- Support assay development, optimization, validation/verification, and performance monitoring (liquid biopsy platforms, NGS, fragment analysis, PCR-based assays).
- Evaluate and interpret genomic profiles and molecular testing data (DNA/RNA sequencing and other platforms).
- Maintain and improve quality systems, QA/QC programs, and continuous quality improvement.
- Support documentation (policies, procedures, SOPs) and regulatory compliance.
- Participate in inspections, audits, proficiency testing, and accreditation activities.
- Investigate quality events/deviations and manage CAPAs.
- Provide consultation on testing strategies and clinically relevant genomic findings; support clinical report preparation/review.
- Mentor/supervise and train molecular technologists/scientists/fellows/junior staff.
- Plan workflows, implement new technologies, improve processes; maintain genomic databases/variant interpretation resources.
- Stay current via literature review and professional development.
Required Qualifications
- PhD in Genetics, Molecular Biology, Genomics, or related field.
- ABMGG certification (Laboratory Genetics and Genomics or Clinical Molecular Genetics and Genomics).
- 3+ years post-fellowship experience in a clinical genomics lab (preferably molecular oncology).
- Knowledge of molecular genetics/genomics/precision oncology.
- Experience/training with NGS, PCR, sequencing, and genomic data interpretation.
- Knowledge of CAP, CLIA, NYS DOH, and/or ISO 15189.
- Analytical/problem-solving, strong communication, multidisciplinary teamwork, strong organization.
- Residency in or willingness to relocate to Phoenix, AZ; full-time onsite required.
Preferred Qualifications
- NYS Certificate of Qualification in molecular oncology and genetic testing.
- Molecular oncology/clinical molecular diagnostics experience.
- Liquid biopsy/ctDNA familiarity; assay validation/quality systems/accreditation experience.
- Clinical variant interpretation/reporting workflow experience; bioinformatics pipeline/database experience.
- Mentoring/supervisory experience; ability to work independently in a team environment.
The Assistant Laboratory Director, Liquid Profiling supports operational, scientific, and regulatory oversight of the Liquid Profiling Laboratory. Assists in development, validation, implementation, and interpretation of advanced molecular/genomic assays used to identify clinically actionable alterations in oncology specimens, including ctDNA and inherited variants relevant to cancer predisposition and pharmacogenomics.
Job Responsibilities
- Ensure quality, compliance, and clinical integrity of high-complexity molecular testing.
- Assist oversight of molecular testing operations in compliance with CAP, CLIA, NYS DOH, ISO 15189, and other regulations.
- Support assay development, optimization, validation/verification, and performance monitoring (liquid biopsy platforms, NGS, fragment analysis, PCR-based assays).
- Evaluate and interpret genomic profiles and molecular testing data (DNA/RNA sequencing and other platforms).
- Maintain and improve quality systems, QA/QC programs, and continuous quality improvement.
- Support documentation (policies, procedures, SOPs) and regulatory compliance.
- Participate in inspections, audits, proficiency testing, and accreditation activities.
- Investigate quality events/deviations and manage CAPAs.
- Provide consultation on testing strategies and clinically relevant genomic findings; support clinical report preparation/review.
- Mentor/supervise and train molecular technologists/scientists/fellows/junior staff.
- Plan workflows, implement new technologies, improve processes; maintain genomic databases/variant interpretation resources.
- Stay current via literature review and professional development.
Required Qualifications
- PhD in Genetics, Molecular Biology, Genomics, or related field.
- ABMGG certification (Laboratory Genetics and Genomics or Clinical Molecular Genetics and Genomics).
- 3+ years post-fellowship experience in a clinical genomics lab (preferably molecular oncology).
- Knowledge of molecular genetics/genomics/precision oncology.
- Experience/training with NGS, PCR, sequencing, and genomic data interpretation.
- Knowledge of CAP, CLIA, NYS DOH, and/or ISO 15189.
- Analytical/problem-solving, strong communication, multidisciplinary teamwork, strong organization.
- Residency in or willingness to relocate to Phoenix, AZ; full-time onsite required.
Preferred Qualifications
- NYS Certificate of Qualification in molecular oncology and genetic testing.
- Molecular oncology/clinical molecular diagnostics experience.
- Liquid biopsy/ctDNA familiarity; assay validation/quality systems/accreditation experience.
- Clinical variant interpretation/reporting workflow experience; bioinformatics pipeline/database experience.
- Mentoring/supervisory experience; ability to work independently in a team environment.