Director, Medicinal Chemistry

Role: Hands-on medicinal chemistry leader specializing in small-molecule drug discovery with a focus on molecular glue degraders. Objectives: advance hit-to-lead optimization, mechanistic hypothesis testing, and candidate selection. Responsibilities: lead SAR development, structure-based design, manage internal and external chemistry teams and CROs, oversee synthesis and scale-up, and apply biophysical techniques for mechanistic understanding. Requirements: PhD in Chemistry or related field with 8+ years (PhD), 10+ years (MS), or 12+ years (BS) experience in small-molecule drug discovery; extensive medicinal chemistry expertise; proven leadership in molecular glue programs, protein–protein interfaces, and E3 ligase biology. Preferred: experience with targeted protein degradation, covalent chemistry, computational tools, and biophysical assays; strong publication or patent record; collaborative skills within multidisciplinary teams. HighValue: small-molecule, targeted protein degradation, molecular glue, hit-to-lead, candidate optimization, structure-based design, CRO management, biophysical techniques. WorkSetup: not specified, likely hybrid based on nature of collaborative research.