Director, Medicinal Chemistry

Role: Lead and co-direct a full-phase antiviral small molecule discovery program, overseeing medicinal chemistry strategy, compound design, and external CRO management. Responsibilities: drive hit-to-lead optimization, guide structure-activity and property-based design, integrate multidisciplinary data (DMPK, safety, virology), and contribute to early-stage discovery efforts; manage external chemistry resources; support patent activities; mentor colleagues. Requirements: PhD in synthetic organic or medicinal chemistry; 8+ years in drug discovery; experience leading small molecule programs from hit-to-lead to candidate nomination; expertise in structure-based design, DMPK issues, and CRO oversight; strong problem-solving, decision-making, and communication skills. HighValue: antiviral therapeutics, small molecule modality, full-phase drug discovery, DMPK & virology collaboration, hybrid onsite in South San Francisco; experience with structural biology and computational chemistry preferred.