Director, LNP Discovery
CRISPR Therapeutics
August 14, 2026
On-site
Boston, MA
Clinical Research and Development
Position Summary
- Lead mRNA delivery efforts, overseeing development of novel LNP (lipid nanoparticle) systems for extrahepatic delivery.
Responsibilities
- Oversee development of novel LNPs (lipid chemistry, composition, formulation process).
- Oversee development of cell-based assays and animal models for LNP testing.
- Lead LNP delivery biology efforts, including protein design and bioconjugation to optimize LNPs.
- Collaborate cross-functionally with pharmacology and programming teams to achieve milestones.
- Drive RNA extrahepatic delivery strategy, with emphasis on IP and key deliverables.
- Stay current on RNA delivery literature; prepare technical reports and white papers.
- Prepare technical documents and manuscripts for IP filings and publications.
- Present scientific findings internally and externally at conferences and industry events.
Minimum Qualifications
- PhD in Pharmaceutical Sciences, Biochemistry, Engineering, Chemistry, or related field.
- 10+ years’ experience with lipid nanoparticles, siRNA, and protein design.
- Demonstrated success translating animal models from mouse to non-human primate.
- Excellent oral and written communication.
- Innovation track record in LNP research (bioconjugation, protein design and/or binder design).
- Strong record keeping skills (eLN).
- Proven research team leadership.
- Ability to synthesize inputs and recommend strategic LNP research approaches.
- Ability to operate at both detailed and high-level scopes; strong navigation.
- Strategic thinking, influence, proactive ownership mindset.
Preferred Qualifications
- Biotech industry experience.
- Knowledge of the drug development process.
Benefits / Compensation
- Base pay range of $195,000 to $215,000+ bonus, equity and benefits.
Application Instructions
- Not provided in the posting.
- Lead mRNA delivery efforts, overseeing development of novel LNP (lipid nanoparticle) systems for extrahepatic delivery.
Responsibilities
- Oversee development of novel LNPs (lipid chemistry, composition, formulation process).
- Oversee development of cell-based assays and animal models for LNP testing.
- Lead LNP delivery biology efforts, including protein design and bioconjugation to optimize LNPs.
- Collaborate cross-functionally with pharmacology and programming teams to achieve milestones.
- Drive RNA extrahepatic delivery strategy, with emphasis on IP and key deliverables.
- Stay current on RNA delivery literature; prepare technical reports and white papers.
- Prepare technical documents and manuscripts for IP filings and publications.
- Present scientific findings internally and externally at conferences and industry events.
Minimum Qualifications
- PhD in Pharmaceutical Sciences, Biochemistry, Engineering, Chemistry, or related field.
- 10+ years’ experience with lipid nanoparticles, siRNA, and protein design.
- Demonstrated success translating animal models from mouse to non-human primate.
- Excellent oral and written communication.
- Innovation track record in LNP research (bioconjugation, protein design and/or binder design).
- Strong record keeping skills (eLN).
- Proven research team leadership.
- Ability to synthesize inputs and recommend strategic LNP research approaches.
- Ability to operate at both detailed and high-level scopes; strong navigation.
- Strategic thinking, influence, proactive ownership mindset.
Preferred Qualifications
- Biotech industry experience.
- Knowledge of the drug development process.
Benefits / Compensation
- Base pay range of $195,000 to $215,000+ bonus, equity and benefits.
Application Instructions
- Not provided in the posting.