Director II, LNP Platform Technology

Role Summary

Director II, LNP Platform Technology is a technical leadership role responsible for innovating and developing the LNP platform. You will work with cross-functional teams to design and develop LNPs/tLNP platform technology in support of AbbVie's pipeline. You will establish and lead the LNP innovation strategy focusing on lipid design, chemistry, formulations, and targeted non-viral delivery systems to enable future products and pipeline growth.

Responsibilities

• Serves as a scientific and technical leader in the organization with special emphasis on lipid nanoparticle (LNP)-based drug delivery systems for nucleic acids.
• Lead the strategy to innovate, develop, and optimize the targeted LNP platform to support programs across therapeutic areas.
• Have a deep understanding of lipid and LNP design principles, stability, scale-up and scale-out processes and their impact on critical product attributes. Ensure successful scale up of drug product formulation production and purification unit operations from bench scale to larger scale in support of a development candidate.
• Prepare LNP-related project plans, timelines, budget projections, and ensure development activities proceed in alignment with key stakeholders in alignment with organizational goals and budget.
• Lead analysis and summarization of complex data sets, and communicate clearly at internal program meetings, cross-functional reviews and governance forums.
• Collaborate with various discovery and development groups across the organization including mRNA, antibody, analytical and process development groups to advance pipeline programs.
• Lead authoring, review and approval of technical reports relevant to the function.
• Manage and mentor a team of more than 10 scientists and associates at AbbVie sites located on the east and west coasts.

Qualifications

• PhD in Chemistry, Biochemistry, Chemical or Bioengineering
• 12+ years (PhD) of experience in pharmaceutical or biotechnology industry
• Strong experience and technical mastery in LNP design and development including analytical characterization and CMC regulatory knowledge
• Demonstrated expertise in developing liquid, frozen and lyophilized formulations of lipid-based nucleic acid formulations through clinical development
• Prior experience leading and mentoring a team of more than 10 scientists/associates