Director, Health Economics & Outcomes Research

Role Summary

Director of Global HEOR to lead and execute health economics and outcomes research activities for the pain program, focusing on prospective, non-interventional studies to support commercialization strategies. Combine strategic oversight with hands-on execution to shape the HEOR strategy, guide study design, and ensure high-quality delivery of research that demonstrates the value of Vertex therapies, beginning with moderate-to-severe acute pain. Reports to the senior director, global HEOR pain.

Responsibilities

• Strategy & Leadership
  • Define and execute the HEOR strategy for prospective non-interventional research aligned with pain program strategy.
  • Represent HEOR perspectives in cross-functional forums and with external partners, aligning research with program and business objectives.
• Study Design & Execution
  • Lead, with vendor support, the development of protocols, investigator brochures, informed consent forms (ICFs), case report forms (CRFs), statistical analysis plans (SAPs), and technical reports.
  • Lead Study Execution Teams (SETs), ensuring efficient, high-quality study execution.
  • Manage study operations, including timelines, deliverables, and budgets; ensure issues are identified and resolved proactively.
  • Support vendor selection and contracting.
  • Coordinate cross-functional review and approval of study-related documents and outputs.
• Data Interpretation & Communication
  • Oversee data analysis, interpretation, scientific rigor, and communication of results, ensuring contextually relevant.
  • Lead development of presentations, manuscripts, and other dissemination activities.
  • Provide clear updates to internal stakeholders and cross-functional teams on study progress and insights.
• Collaboration & Representation
  • Partner with internal stakeholders, such as Medical Affairs, to ensure alignment in study design, execution, and dissemination.
  • Represent Vertex externally with investigators, collaborators, and scientific experts in protocol development and study conduct.

Qualifications

• Advanced degree (PhD, PharmD, MD, or MS with significant experience) in epidemiology, health economics, clinical research, health services research, public health, or related field.
• 10+ years of experience in HEOR, clinical research, or observational studies in academia, industry, or equivalent.
• Proven experience leading the design, execution, and analysis of prospective and non-interventional studies, including site feasibility, case report form development, and recruitment.
• Strong knowledge of Good Clinical Practice (GCP), biostatistics, clinical research methods, and study design.
• Demonstrated ability to manage vendors, budgets, and complex project deliverables.
• Experience preparing publications and presenting scientific findings.

Skills

• Strategic thinker with the ability to connect evidence generation to business and clinical priorities.
• Hands-on project leader with strong execution skills and attention to detail.
• Excellent oral and written communication skills; able to translate complex science into clear, actionable insights.
• Strong organizational and problem-solving skills with ability to manage multiple priorities simultaneously.
• Collaborative team player who builds effective partnerships internally and externally.
• Ability to thrive in a fast-paced, matrix environment and balance both independent and team-based work.