Director, Head of High-Throughput in vitro ADME
Takeda
10 hours ago
Remote friendly (Boston, MA)
United States
$177,000 - $278,080 USD yearly
Clinical Research and Development
Objective / Purpose:
- Build and direct Takeda’s high-throughput in vitro ADME capabilities in support of small- and large-molecule discovery programs.
- Define strategy, oversee operations, and drive technology innovation across ADME science, laboratory automation, and robotics; deliver robust, high-quality ADME data to support rapid decision-making in DMTA cycles.
Accountabilities:
- Strategic Leadership & Vision: define and execute a multi-year roadmap; shape an enterprise service-oriented operating model (capacity/capability/flexibility); champion innovation in assay design, detection, automation, and data workflows.
- Team Leadership & People Development: lead and mentor a scientists/research associates team; build a culture of rigor, operational excellence, safety, and customer focus using KPIs (e.g., cycle time, success rate, capacity utilization, cost-per-data point); drive Director-level talent development and performance management.
- High-Throughput ADME Operations: oversee design/execution/continuous improvement of an in vitro ADME panel, including metabolic stability/clearance (microsomes, hepatocytes, S9), CYP inhibition/induction, permeability (Caco-2/MDCK/PAMPA), plasma protein/tissue binding, transporter/mechanistic assays; support small- and large-molecule modalities; own validation/QC/SOPs and corrective actions (root-cause analysis).
- Laboratory Automation, Robotics & Miniaturization: lead automation/robotics strategy in ADME; miniaturize assays up to 1536-well formats through feasibility, optimization, and technology transfer; integrate instruments/software into end-to-end workflows; partner with automation/engineering and informatics teams to connect instruments with LIMS/ELN, data pipelines, and analytical platforms.
- Cross-Functional Collaboration: serve as primary ADME service leader for DMPK, medicinal chemistry, biology, pharmacology, translational sciences, and data science; translate portfolio/project needs into assay strategies, capacity plans, and timelines; coordinate with CROs/vendors/academia while maintaining quality and strategic alignment.
- Quality, Compliance & Continuous Improvement: ensure scientific quality, data integrity, and safety; define/monitor KPIs and use Lean/Six Sigma/DoE for continuous improvement; oversee investigations and CAPA.
Qualifications:
- Ph.D. in Pharmaceutical Sciences/Drug Metabolism/Biochemistry/Pharmacology or related with 10+ years industry experience; or M.S. with 16+ years; or B.S. with 18+ years in pharma/biotech R&D.
- Extensive in vitro ADME expertise (method development, validation, deployment).
- Experience providing ADME services (CRO or internal service group) with a service/customer mindset.
- Director-level leadership in high-throughput, complex operations.
- Demonstrated experience with lab automation/robotics (selection, implementation, lifecycle management).
- Track record miniaturizing ADME assays (data quality, robustness, throughput).
- Experience supporting both small- and large-molecule discovery.
- Familiarity with LIMS/ELN, instrument integration, and data analysis/visualization tools.
Additional Information (role-related):
- Hybrid role based in Cambridge, MA.
Benefits:
- U.S. base salary range: $174,500.00–$274,230.00.
- Eligible for incentives; may participate in medical/dental/vision, 401(k) with match, disability, life insurance, tuition reimbursement, paid volunteer time off, holidays, and well-being benefits; up to 80 hours sick time/year; new hires accrue up to 120 hours paid vacation.
Application Instructions:
- By clicking “Apply,” you confirm your application process will commence and your information will be processed according to Takeda’s Privacy Notice and Terms of Use; you attest that submitted information is true to the best of your knowledge.
- Build and direct Takeda’s high-throughput in vitro ADME capabilities in support of small- and large-molecule discovery programs.
- Define strategy, oversee operations, and drive technology innovation across ADME science, laboratory automation, and robotics; deliver robust, high-quality ADME data to support rapid decision-making in DMTA cycles.
Accountabilities:
- Strategic Leadership & Vision: define and execute a multi-year roadmap; shape an enterprise service-oriented operating model (capacity/capability/flexibility); champion innovation in assay design, detection, automation, and data workflows.
- Team Leadership & People Development: lead and mentor a scientists/research associates team; build a culture of rigor, operational excellence, safety, and customer focus using KPIs (e.g., cycle time, success rate, capacity utilization, cost-per-data point); drive Director-level talent development and performance management.
- High-Throughput ADME Operations: oversee design/execution/continuous improvement of an in vitro ADME panel, including metabolic stability/clearance (microsomes, hepatocytes, S9), CYP inhibition/induction, permeability (Caco-2/MDCK/PAMPA), plasma protein/tissue binding, transporter/mechanistic assays; support small- and large-molecule modalities; own validation/QC/SOPs and corrective actions (root-cause analysis).
- Laboratory Automation, Robotics & Miniaturization: lead automation/robotics strategy in ADME; miniaturize assays up to 1536-well formats through feasibility, optimization, and technology transfer; integrate instruments/software into end-to-end workflows; partner with automation/engineering and informatics teams to connect instruments with LIMS/ELN, data pipelines, and analytical platforms.
- Cross-Functional Collaboration: serve as primary ADME service leader for DMPK, medicinal chemistry, biology, pharmacology, translational sciences, and data science; translate portfolio/project needs into assay strategies, capacity plans, and timelines; coordinate with CROs/vendors/academia while maintaining quality and strategic alignment.
- Quality, Compliance & Continuous Improvement: ensure scientific quality, data integrity, and safety; define/monitor KPIs and use Lean/Six Sigma/DoE for continuous improvement; oversee investigations and CAPA.
Qualifications:
- Ph.D. in Pharmaceutical Sciences/Drug Metabolism/Biochemistry/Pharmacology or related with 10+ years industry experience; or M.S. with 16+ years; or B.S. with 18+ years in pharma/biotech R&D.
- Extensive in vitro ADME expertise (method development, validation, deployment).
- Experience providing ADME services (CRO or internal service group) with a service/customer mindset.
- Director-level leadership in high-throughput, complex operations.
- Demonstrated experience with lab automation/robotics (selection, implementation, lifecycle management).
- Track record miniaturizing ADME assays (data quality, robustness, throughput).
- Experience supporting both small- and large-molecule discovery.
- Familiarity with LIMS/ELN, instrument integration, and data analysis/visualization tools.
Additional Information (role-related):
- Hybrid role based in Cambridge, MA.
Benefits:
- U.S. base salary range: $174,500.00–$274,230.00.
- Eligible for incentives; may participate in medical/dental/vision, 401(k) with match, disability, life insurance, tuition reimbursement, paid volunteer time off, holidays, and well-being benefits; up to 80 hours sick time/year; new hires accrue up to 120 hours paid vacation.
Application Instructions:
- By clicking “Apply,” you confirm your application process will commence and your information will be processed according to Takeda’s Privacy Notice and Terms of Use; you attest that submitted information is true to the best of your knowledge.