Director, Global Health Economics & Outcomes Research (HEOR)

Role Summary

Director, Global HEOR, to lead the strategy and execution of how we define, substantiate, and communicate the value of one or more medicines approaching commercialization. Based in Waltham, MA, this role ensures alignment with payer and HTA decision-making from clinical development through real-world evidence generation and payer engagement.

Responsibilities

• Informing development strategies from HEOR / market access perspective
• Represent the HEOR and market access perspective in internal clinical development and regulatory forums
• Provide critical input into clinical development plans, including protocol design, endpoint selection, and other aspects of clinical trial evidence generation, to ensure alignment with future payer and HTA expectations
• Communication of value to payers and HTA bodies
• Lead development of AMCP dossiers for US payers
• Lead development of cost-effectiveness models for NICE and other HTA bodies requiring formal cost-effectiveness analyses
• Serve as a core team member for HTA submissions outside the US, with responsibility for shaping and stress-testing value narratives included in pricing and reimbursement dossiers and interpreting and recommending evidence to support such narratives, in a way that optimizes both credibility and relevance for payer decision-making
• Make substantial contributions to other payer communication materials (e.g., Medical Value Liaison slide decks) and launch readiness activities as needed
• Leading real-world evidence strategy and execution of real-world analyses
• Lead planning of real-world evidence generation activities to address evidence gaps as needed for informing decision-making by payers, HTA bodies, and clinicians
• Oversee execution of real-world data analyses, ensuring analytical rigor and fitness for purpose
• Interpret and translate results from real-world analyses into peer-reviewed publications and other external communications intended to meaningfully inform clinical practice and payer/HTA decision-making

Qualifications

• Bachelor’s degree or equivalent experience in a relevant field such as economics, public health, epidemiology, biostatistics, health policy, life sciences, or a related discipline
• Advanced degrees (Master’s, PhD, PharmD, MD) are welcome but not required
• 10+ years of progressive experience in HEOR, health analytics, value demonstration, market access, or a closely related quantitative or scientific field
• Demonstrated success leading complex evidence‑generation, modeling, or analytical programs within biopharma, healthcare consulting, payer organizations, or academic research environments
• Experience influencing senior leaders and driving strategic decisions through evidence and structured analysis
• Skills and qualities:
  • Analytical ability: Strong reasoning and structured problem‑solving capabilities, with curiosity, persistence, and creativity to tackle complex, open‑ended problems
  • Sophisticated understanding of evidence: Clear judgment about what different analytical methodologies can and cannot tell you, and what makes an analysis more or less robust
  • Understanding of value frameworks: Familiarity with decision‑making frameworks that inform how medicines are valued, priced, and reimbursed
  • Strong mathematical intuition: Deep understanding of how numbers work, how models behave, and how assumptions propagate through analyses
  • Critical evaluation of scientific literature: Ability to read, interpret, and rigorously critique medical, scientific, and health economics publications
  • Biological and clinical literacy: Sufficient grounding in biology and clinical science to engage effectively with development teams and external clinical experts
  • Results orientation: Focus on organizational priorities—balancing rigor with pragmatism and avoiding analysis for analysis’ sake
  • Bias toward solutions and progress: Mindset oriented toward finding solutions, offering alternatives, and maintaining momentum

Education

• Bachelor’s degree or equivalent experience in a relevant field such as economics, public health, epidemiology, biostatistics, health policy, life sciences, or a related discipline
• Advanced degrees (Master’s, PhD, PharmD, MD) are welcome but not required