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Director, DMPK

Denali Therapeutics
September 02, 2026
Full-time
Remote friendly (South San Francisco, CA)
Worldwide
Clinical Research and Development
Role: Lead and manage the DMPK group within Nonclinical Safety Assessment and Development Sciences, providing scientific and strategic input to advance blood-brain-barrier penetrant biotherapeutics from Discovery through IND-enabling studies and registration. Responsibilities: oversee PK, drug disposition, biodistribution, and translational pharmacology strategies, contribute to project team decisions, design nonclinical PK/PD studies, analyze and communicate data to stakeholders, author regulatory sections, and lead staff development. Requirements: PhD in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology/Toxicology, or related field; 10+ years of relevant experience including 8+ years in leadership and mentorship; expertise in biotherapeutic drug disposition, PK, and translational science, with a record of advancing candidates through early development milestones. HighValue: biotherapeutics, blood-brain barrier penetration, PK/PD, CTA/IND-enabling studies, regulatory filings, cross-functional collaboration, leadership in nonclinical drug development. WorkSetup: not specified; likely office-based with leadership responsibilities.