Director – Discovery ADME Project Leader (Bioconjugates)
Eli Lilly and Company
8 hours ago
Remote friendly (Louisville, CO)
United States
Clinical Research and Development
Discovery ADME Project Leader (Antibody Drug Conjugates)
Responsibilities:
- Keep safety as a priority.
- Develop and implement integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses, and regulatory expectations.
- Drive integrated ADME strategy by aligning pharmacokinetics, metabolism, and mechanistic disposition data with early safety signals.
- Interpret exposure–toxicity relationships, therapeutic index, and off-target liabilities to de-risk programs and enable data-driven candidate selection.
- Integrate ADME, pharmacology, and toxicology to support translational simulations/modeling for dose selection and PK/PD, efficacy, and safety study design.
- Define stage-, modality-, and issue-appropriate screening/decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design and optimization (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as ADME single-point-of-accountability on cross-functional program teams; translate ADME findings into design/test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions.
- Contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation; represent ADME in governance and leadership reviews.
- Implement best practices, assay innovation, and automation where appropriate; improve data reporting/knowledge management/decision frameworks.
- Seek and leverage AI/agentic tools to pipeline and interpret data and share results.
- Maintain inspection-ready documentation and align with regulatory expectations.
- Mentor, teach, and grow junior scientists.
Basic Qualifications:
- PhD in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical or Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field; or Bachelor’s with 10+ years experience.
- 6+ years of post-graduation industry experience in drug discovery, driving discovery teams across the Design, Make, Test, Analyze lifecycle.
Additional Skills/Preferences:
- Deep ADME expertise; working knowledge of medicinal chemistry and bioconjugates.
- Exceptional written/verbal communication; ability to navigate ambiguity and global cross-functional collaboration.
- Ability to translate complex technical concepts into strategic value for senior leadership.
Benefits:
- Eligibility for a company-sponsored 401(k), pension, vacation benefits; medical/dental/vision/prescription benefits; flexible benefits; life insurance/death benefits; certain time off and leave of absence; well-being benefits (e.g., employee assistance program, fitness benefits, clubs/activities).
- Full-time employees also eligible for a company bonus (depending on company and individual performance).
Application instructions:
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation
Responsibilities:
- Keep safety as a priority.
- Develop and implement integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses, and regulatory expectations.
- Drive integrated ADME strategy by aligning pharmacokinetics, metabolism, and mechanistic disposition data with early safety signals.
- Interpret exposure–toxicity relationships, therapeutic index, and off-target liabilities to de-risk programs and enable data-driven candidate selection.
- Integrate ADME, pharmacology, and toxicology to support translational simulations/modeling for dose selection and PK/PD, efficacy, and safety study design.
- Define stage-, modality-, and issue-appropriate screening/decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design and optimization (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as ADME single-point-of-accountability on cross-functional program teams; translate ADME findings into design/test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions.
- Contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation; represent ADME in governance and leadership reviews.
- Implement best practices, assay innovation, and automation where appropriate; improve data reporting/knowledge management/decision frameworks.
- Seek and leverage AI/agentic tools to pipeline and interpret data and share results.
- Maintain inspection-ready documentation and align with regulatory expectations.
- Mentor, teach, and grow junior scientists.
Basic Qualifications:
- PhD in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical or Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field; or Bachelor’s with 10+ years experience.
- 6+ years of post-graduation industry experience in drug discovery, driving discovery teams across the Design, Make, Test, Analyze lifecycle.
Additional Skills/Preferences:
- Deep ADME expertise; working knowledge of medicinal chemistry and bioconjugates.
- Exceptional written/verbal communication; ability to navigate ambiguity and global cross-functional collaboration.
- Ability to translate complex technical concepts into strategic value for senior leadership.
Benefits:
- Eligibility for a company-sponsored 401(k), pension, vacation benefits; medical/dental/vision/prescription benefits; flexible benefits; life insurance/death benefits; certain time off and leave of absence; well-being benefits (e.g., employee assistance program, fitness benefits, clubs/activities).
- Full-time employees also eligible for a company bonus (depending on company and individual performance).
Application instructions:
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation