Director – Discovery ADME Project Leader (Bioconjugates)
Eli Lilly and Company
9 hours ago
Remote friendly (Boston, MA)
United States
Clinical Research and Development
Discovery ADME Project Leader (Antibody Drug Conjugates)
Responsibilities:
- Keep Safety as a priority.
- Develop and implement integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses, and regulatory expectations.
- Drive comprehensive ADME strategy by aligning PK, metabolism, and mechanistic disposition data with early safety signals.
- Interpret exposure–toxicity relationships, therapeutic index, and off-target liabilities to de-risk programs and support data-driven candidate selection.
- Integrate ADME, pharmacology, and toxicology to enable translational simulations and modeling for dose selection and PK/PD, efficacy, and safety study design.
- Define stage-, modality-, and issue-appropriate screening and decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design and optimization (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as ADME single-point-of-accountability on cross-functional program teams; translate findings into design/test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; contribute to go/no-go decisions.
- Represent ADME in portfolio governance and leadership reviews; implement assay best practices, innovation, and automation.
- Drive continuous improvement in data reporting, knowledge management, and decision frameworks; leverage AI/agentic tools where possible.
- Maintain inspection-ready documentation; mentor and grow junior scientists.
Basic Qualifications:
- PhD in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field; or Bachelor’s with 10+ years experience.
- 6+ years post-graduation industry experience in drug discovery, driving teams through the Design, Make, Test, Analyze flywheel.
Additional/Preferred Skills:
- Deep ADME expertise with working knowledge of medicinal chemistry and bioconjugates.
- Exceptional written/verbal communication; ability to navigate ambiguity and global cross-functional collaboration.
- Ability to translate complex technical concepts into strategic value for senior leadership and partners.
Benefits:
- Eligible for company bonus; comprehensive benefits program including 401(k), pension, vacation; medical/dental/vision/prescription; flexible benefits; life insurance/death benefits; time off/leave; well-being benefits.
Application Instructions:
- If you require accommodation to submit a resume, complete the accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation
Responsibilities:
- Keep Safety as a priority.
- Develop and implement integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses, and regulatory expectations.
- Drive comprehensive ADME strategy by aligning PK, metabolism, and mechanistic disposition data with early safety signals.
- Interpret exposure–toxicity relationships, therapeutic index, and off-target liabilities to de-risk programs and support data-driven candidate selection.
- Integrate ADME, pharmacology, and toxicology to enable translational simulations and modeling for dose selection and PK/PD, efficacy, and safety study design.
- Define stage-, modality-, and issue-appropriate screening and decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design and optimization (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as ADME single-point-of-accountability on cross-functional program teams; translate findings into design/test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; contribute to go/no-go decisions.
- Represent ADME in portfolio governance and leadership reviews; implement assay best practices, innovation, and automation.
- Drive continuous improvement in data reporting, knowledge management, and decision frameworks; leverage AI/agentic tools where possible.
- Maintain inspection-ready documentation; mentor and grow junior scientists.
Basic Qualifications:
- PhD in Pharmaceutical Sciences, Pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related field; or Bachelor’s with 10+ years experience.
- 6+ years post-graduation industry experience in drug discovery, driving teams through the Design, Make, Test, Analyze flywheel.
Additional/Preferred Skills:
- Deep ADME expertise with working knowledge of medicinal chemistry and bioconjugates.
- Exceptional written/verbal communication; ability to navigate ambiguity and global cross-functional collaboration.
- Ability to translate complex technical concepts into strategic value for senior leadership and partners.
Benefits:
- Eligible for company bonus; comprehensive benefits program including 401(k), pension, vacation; medical/dental/vision/prescription; flexible benefits; life insurance/death benefits; time off/leave; well-being benefits.
Application Instructions:
- If you require accommodation to submit a resume, complete the accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation