Director, Delivery Sciences

Company Summary

Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s lead program is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.

We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.

Position Summary

Korro Bio is seeking a Director, Delivery Sciences within its Platform group to lead the development and evaluation of novel delivery systems for oligonucleotide therapeutics targeting the liver and extrahepatic tissues. This role will be instrumental in advancing the RNA editing platform, OPERA, by driving delivery strategy, coordinating with external partners, and collaborating across a highly matrixed organization. The ideal candidate will possess strong scientific acumen, demonstrate effective communication, and present results clearly to cross-functional project teams.

Key Responsibilities

• Build and lead all delivery efforts for oligonucleotide conjugates including GalNAc conjugates and other extrahepatic delivery strategies.
• Build capabilities in the areas of delivery chemistries including lipid excipients, endosomal escape enhancers and other areas including nanoparticle-based delivery technologies.
• Actively collaborate with medicinal chemistry and other cross functional teams to support pipeline projects.
• Manage mentor and grow a diverse high-performing scientific team.
• Clear communication of results to different audiences including scientific staff and senior leadership.
• Proactively identify potential obstacles and devise solutions to mitigate risk.
• Foster a culture of of excellence, accountability and innovation within the delivery team.
• Build a network of relevant academic and industry relationships and encourage the external presentation or presentation for the delivery team.
• PhD in a scientific discipline with 8+ years’ experience in delivery chemistry with a focus on oligonucleotides.
• Demonstrated expertise in nucleic acid delivery platforms and technologies.
• Outstanding oral and written communication skills.
• Proven ability to work effectively across disciplines in a fast-paced environment.
• Previous experience in oligonucleotide or RNA based drug discovery.
• Prior leadership experience in delivery strategy development or platform innovation.
• Please note that will be an onsite position with 50% work in the lab.

Benefits

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.