Director, Commercial Assessments

Role Summary

Director, Commercial Assessments will play a pivotal role in shaping Madrigal’s long-term growth by evaluating external opportunities beyond the current portfolio, with a focus on MASH and potential adjacencies. You will integrate scientific understanding, market analytics, and commercial strategy to assess opportunity attractiveness, inform investment decisions, and guide portfolio direction. This role requires strong analytical capabilities, the ability to interpret complex secondary data, and a solid grounding in the science underpinning liver and metabolic diseases.

Responsibilities

• Opportunity Assessment: Lead commercial and strategic evaluations of external assets, indications, and adjacencies relevant to Madrigal‚Äôs therapeutic focus
• Market Analytics: Conduct secondary analytics to quantify market size, patient populations, competitive landscapes, and potential revenue opportunities
• Scientific Integration: Leverage deep scientific and clinical understanding to contextualize market findings and strengthen opportunity evaluations
• Due Diligence Support: Partner on due diligence efforts for potential partnerships, collaborations, and in-licensing opportunities.
• Market Research Leadership: Design and manage both primary and secondary market research to validate assumptions and assess opportunity attractiveness
• Forecasting & Valuation: Develop and refine forecasting models, scenario analyses, and valuation frameworks to support portfolio prioritization and BD decisions
• Strategic Insights: Translate complex data into concise, actionable insights for senior leadership and Board-level discussions
• Cross-Functional Collaboration: Work closely with R&D, Finance, Medical Affairs, and Commercial to align scientific and commercial perspectives
• Competitive Intelligence: Maintain a strong understanding of industry trends, emerging mechanisms, and key players across MASH and related metabolic disease areas
• Analytical Tool Development: Establish analytical tools and structured approaches to enhance rigor and consistency in commercial assessment processes

Qualifications

• Education: Advanced scientific degree (PhD, MBA, PharmD, MD or advanced science degree) preferred
• Experience: 12-15 years of professional experience
• Background: Biopharma, management consulting, or corporate/business development with significant exposure to commercial analytics, forecasting, and opportunity assessment
• Therapeutic Focus: Experience across MASH / Liver, metabolic, cardiovascular, or related areas strongly preferred
• Global Experience: Global or cross-regional experience desirable
• Technical: Advanced proficiency in Excel, PowerPoint, and data visualization tools (e.g., Tableau)
• Data Sources: Expertise in secondary data sources such as IQVIA, Evaluate, GlobalData, and epidemiological datasets
• Analytics: Ability to integrate large data sets into actionable insights through structured analysis

Skills

• Strong analytical and problem-solving skills with consulting-level rigor
• Deep scientific and clinical literacy in metabolic and liver disease mechanisms
• Excellent communication and storytelling skills for senior leadership audiences
• Proven ability to manage multiple high-priority projects with tight timelines
• Demonstrated cross-functional leadership and collaboration across commercial and scientific teams
• Experience in vendor management and external research partnerships
• Background in business development or due diligence a strong plus

Education

• Advanced scientific degree (PhD, MBA, PharmD, MD or advanced science degree) preferred
• 12-15 years of professional experience
• Background in biopharma, management consulting, or corporate/business development with significant exposure to commercial analytics, forecasting, and opportunity assessment
• Experience working across MASH / Liver, metabolic, cardiovascular, or related therapeutic areas strongly preferred
• Global or cross-regional experience desirable
• Advanced proficiency in Excel, PowerPoint, and data visualization tools (e.g., Tableau)
• Expertise in secondary data sources such as IQVIA, Evaluate, GlobalData, and epidemiological datasets
• Ability to integrate large data sets into actionable insights through structured analysis