Director, Clinical Sciences

Role Summary

Director, Clinical Sciences at Maze Therapeutics. Hands-on role advancing the APOL1 program for chronic kidney disease; design and implement clinical studies, author protocols and regulatory documents, and collaborate with investigators and advocacy groups to ensure operational excellence. Translate genetic insights into actionable clinical plans and deliver high-quality data to drive program success. Opportunity to contribute across multiple programs in a fast-paced, mission-driven environment.

Responsibilities

• Participate in the design, execution, and analysis of clinical trials for the APOL1 program and other clinical stage assets at Maze
• Author and review clinical-regulatory documents, including protocols and amendments, informed consents, study reports, and SAPs
• Prepare and deliver scientific presentations and other communication materials for internal and external stakeholders, including investigators and other Maze collaborators
• Collaborate with scientific thought leaders and patient advocacy groups to gain insights that inform clinical development plans
• Partner with Clinical Development Operations to identify and select study investigators and sites and cultivate strong, trust-based relationships with study investigators
• Partner with Clinical Development Operations to identify, select, and oversee vendors and CROs to support program needs
• Lead the development and integration of timelines and budgets for clinical activities, ensuring alignment with overall company goals and cross-functional input from project management, CMC, nonclinical development, regulatory affairs, and other stakeholders

Qualifications

• Advanced degree in health sciences (PhD/MD/PharmD) with a minimum of 3+ years of drug development industry experience
• Experience in the design and conduct of clinical trials, including preparation of study-specific documents and training materials, data monitoring and review, and assessment of protocol deviations
• Experience in clinical data analysis and scientific presentations
• A strong commitment to building collaborative relationships with investigators, site study staff, patient advocacy groups, and other third parties
• Exceptional organizational, analytical, and communication skills, enabling translation of objectives into actionable plans that deliver high-quality data on time and within budget
• A proactive and adaptable mindset with a commitment to ethical standards and a focus on team and corporate success
• Willingness to travel domestically and internationally (up to ~20%) for vendor visits, industry conferences, regulatory meetings, advisory boards, and other essential gatherings

Skills

• Clinical trial design and execution
• Regulatory document preparation (protocols, amendments, informed consents, study reports, SAPs)
• Scientific communication and data presentation
• Relationship management with investigators, sites, vendors, and patient advocacy groups
• Budgeting and timeline development for clinical activities
• Cross-functional collaboration across clinical development, regulatory affairs, CMC, nonclinical development, and project management

Education

• Advanced degree in health sciences (PhD/MD/PharmD)

Additional Requirements

• Willingness to travel domestically and internationally (up to ~20%)