Director, Clinical Research
Alnylam Pharmaceuticals
August 12, 2026
Remote friendly (Cambridge, MA)
United States
Clinical Research and Development
Hybrid role (2 days/week onsite) in Cambridge, MA or Philadelphia, PA.
Key Responsibilities
- Strategic leader providing a strong, clear voice for the clinical program.
- Develop creative but realistic drug development approaches; lead clinical efforts to secure global regulatory approvals.
- Oversight of trial conduct and safety.
- Provide strategic consultation and guidance to Research on decisions with significant clinical components.
- Collaborate with Preclinical, Regulatory Affairs, and Medical Affairs to integrate product development plans.
- Accountable for relevant timelines and deliverables via Clinical Research and Operations.
- Supervise major written deliverables (regulatory submissions, original articles, abstracts) and presentation materials.
- Final review and sign-off on controlled documents (protocols, investigator brochures, informed consent forms).
- Influence internal and external audiences in a highly visible, high-impact manner.
Qualifications
- MD with strong research background or MD PhD with best-in-class clinical and/or research training (research support; peer-reviewed publications).
- Board Certification (or equivalent) or specialist training in cardiology.
- Desirable: expertise in heart failure and/or amyloidosis.
- 3+ years industry experience or equivalent clinical academic experience.
- Sound scientific and clinical judgment.
- Familiarity with clinical research/trial design (including biostatistics) and regulatory agency organization, guidelines, and practices.
- Ability to present and document complex medical/clinical concepts (written and oral).
- Demonstrated problem-solving with superior judgment.
- Outstanding leadership and collaboration in a matrix environment.
- Experience working with biotech/pharma partners.
Benefits (from job description)
- Medical, dental, and vision; life and disability; lifestyle reimbursement; flexible spending/HSAs; 401(k) with company match; paid time off, wellness days, holidays, and recharge breaks; family resources and leave.
U.S. Pay Range: $255,000.00 - $345,000.00 (eligible for annual short-term incentive and annual long-term incentive/equity).
Key Responsibilities
- Strategic leader providing a strong, clear voice for the clinical program.
- Develop creative but realistic drug development approaches; lead clinical efforts to secure global regulatory approvals.
- Oversight of trial conduct and safety.
- Provide strategic consultation and guidance to Research on decisions with significant clinical components.
- Collaborate with Preclinical, Regulatory Affairs, and Medical Affairs to integrate product development plans.
- Accountable for relevant timelines and deliverables via Clinical Research and Operations.
- Supervise major written deliverables (regulatory submissions, original articles, abstracts) and presentation materials.
- Final review and sign-off on controlled documents (protocols, investigator brochures, informed consent forms).
- Influence internal and external audiences in a highly visible, high-impact manner.
Qualifications
- MD with strong research background or MD PhD with best-in-class clinical and/or research training (research support; peer-reviewed publications).
- Board Certification (or equivalent) or specialist training in cardiology.
- Desirable: expertise in heart failure and/or amyloidosis.
- 3+ years industry experience or equivalent clinical academic experience.
- Sound scientific and clinical judgment.
- Familiarity with clinical research/trial design (including biostatistics) and regulatory agency organization, guidelines, and practices.
- Ability to present and document complex medical/clinical concepts (written and oral).
- Demonstrated problem-solving with superior judgment.
- Outstanding leadership and collaboration in a matrix environment.
- Experience working with biotech/pharma partners.
Benefits (from job description)
- Medical, dental, and vision; life and disability; lifestyle reimbursement; flexible spending/HSAs; 401(k) with company match; paid time off, wellness days, holidays, and recharge breaks; family resources and leave.
U.S. Pay Range: $255,000.00 - $345,000.00 (eligible for annual short-term incentive and annual long-term incentive/equity).