Director, Clinical Research
Alnylam Pharmaceuticals
June 30, 2026
Remote friendly (Philadelphia, PA)
United States
Clinical Research and Development
Hybrid (2 days/week onsite) physician drug developer clinical leadership role in a clinical development program for ATTR amyloidosis.
Key Responsibilities:
- Strategic leader providing a strong, clear voice for the clinical program.
- Develop creative but realistic drug development approaches; lead clinical efforts to secure global regulatory approvals.
- Oversight of trial conduct and safety.
- Provide strategic consultation and guidance to Research for decisions with clinical implications.
- Collaborate closely with Preclinical, Regulatory Affairs, and Medical Affairs to integrate product development plans.
- Accountable for clinical research and operations timelines and deliverables.
- Supervise major written deliverables (regulatory submissions, articles, abstracts) and presentation materials.
- Final review and sign-off for controlled documents (protocols, investigator brochures, informed consent forms).
- Influence internal and external audiences.
Qualifications:
- MD with strong research background or MD/PhD with top-tier clinical and/or research training (research support and peer-reviewed publications).
- Board Certification (or equivalent) or specialist training in cardiology.
- Desirable: expertise in heart failure and/or amyloidosis.
- 3+ years industry experience or equivalent clinical academic experience.
- Sound scientific and clinical judgment.
- Familiarity with clinical research/trial design (including biostatistics) and regulatory organization/guidelines.
- Ability to present and document complex medical/clinical concepts (written and oral).
- Strong leadership and collaboration in a matrix environment.
- Experience working with biotech/pharma partners.
- Thrives in an entrepreneurial biotech environment.
Benefits (as stated): Medical, dental, vision; life/disability; lifestyle reimbursement; flexible spending/HSAs; 401(k) match; paid time off, wellness days, holidays, recharge breaks; family resources and leave.
Pay range (as stated): $255,000.00–$345,000.00 base; eligible for annual short-term incentive and annual long-term incentive.
Key Responsibilities:
- Strategic leader providing a strong, clear voice for the clinical program.
- Develop creative but realistic drug development approaches; lead clinical efforts to secure global regulatory approvals.
- Oversight of trial conduct and safety.
- Provide strategic consultation and guidance to Research for decisions with clinical implications.
- Collaborate closely with Preclinical, Regulatory Affairs, and Medical Affairs to integrate product development plans.
- Accountable for clinical research and operations timelines and deliverables.
- Supervise major written deliverables (regulatory submissions, articles, abstracts) and presentation materials.
- Final review and sign-off for controlled documents (protocols, investigator brochures, informed consent forms).
- Influence internal and external audiences.
Qualifications:
- MD with strong research background or MD/PhD with top-tier clinical and/or research training (research support and peer-reviewed publications).
- Board Certification (or equivalent) or specialist training in cardiology.
- Desirable: expertise in heart failure and/or amyloidosis.
- 3+ years industry experience or equivalent clinical academic experience.
- Sound scientific and clinical judgment.
- Familiarity with clinical research/trial design (including biostatistics) and regulatory organization/guidelines.
- Ability to present and document complex medical/clinical concepts (written and oral).
- Strong leadership and collaboration in a matrix environment.
- Experience working with biotech/pharma partners.
- Thrives in an entrepreneurial biotech environment.
Benefits (as stated): Medical, dental, vision; life/disability; lifestyle reimbursement; flexible spending/HSAs; 401(k) match; paid time off, wellness days, holidays, recharge breaks; family resources and leave.
Pay range (as stated): $255,000.00–$345,000.00 base; eligible for annual short-term incentive and annual long-term incentive.