Director, Clinical Research

Role: Lead clinical development as a physician-scientist for RNAi therapeutics in ATTR amyloidosis, providing clinical leadership and strategic guidance. Responsibilities: oversee trial conduct and safety, develop development strategies to secure regulatory approvals, collaborate across functions (Research, Regulatory, Medical Affairs), ensure timely delivery of clinical and regulatory documents, and serve as a key external spokesperson. Qualifications: MD or MD/PhD with research background, board certification or equivalent in cardiology, 3+ years industry or academic experience, expertise in clinical research, trial design, biostatistics, and regulatory practices. Preferred: experience with amyloidosis or heart failure. High-Value: RNAi modality, rare genetic disease focus, late-stage development, global regulatory engagement, matrix collaboration, hybrid onsite in Cambridge, MA or Philadelphia, PA, with some travel.