Director, Clinical Pharmacology Lead

Role Summary

Janux Therapeutics is seeking a hands-on, execution-driven Clinical Pharmacology Lead to support the design, analysis, and interpretation of clinical pharmacology strategies across our development programs. This role is ideal for a scientific contributor who thrives on working directly with data, ensuring high-quality PK analysis, and enabling data-informed decisions for dose selection and regulatory filings. Location: On-site in San Diego, CA.

Responsibilities

• Serve as the Clinical Pharmacology Lead across multiple programs, owning the execution of clinical pharmacology plans from IND through early clinical development.
• Design and oversee PK, PK/PD, and exposure–response analyses to support dose selection, study design, and benefit-risk assessments.
• Lead the development and execution of clinical pharmacology components of studies, including food effect, drug–drug interaction, organ impairment, and QT assessments.
• Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs, briefing books) and support regulatory interactions.
• Ensure proper bioanalytical sampling strategies, assay validation, and data quality across studies.
• Collaborate with Translational Medicine and Biomarker teams to integrate mechanistic and biomarker data into PK/PD interpretation.
• Work closely with Biometrics and external modeling partners to support population PK and exposure–response modeling.
• Stay current with regulatory guidance and scientific advances in clinical pharmacology, applying best practices to development programs.
• Contribute to program-level planning and prioritization based on pharmacological insights and development risk.
• Other activities as required.

Qualifications

• Required: Ph.D., Pharm.D., or equivalent in Clinical Pharmacology, Pharmaceutical Sciences, or a related field.
• Required: 6+ years of experience in clinical pharmacology and/or pharmacometrics in the biotech or pharmaceutical industry.
• Required: Direct experience designing and executing early-phase clinical studies, including healthy volunteer studies.
• Required: Strong expertise in PK analysis and exposure–response interpretation; experience in oncology or biologics preferred.
• Required: Familiarity with T cell engagers (TCE) and managing external Clinical Pharmacology resources.
• Required: Proven track record of contributing to regulatory submissions and engaging with health authorities.
• Required: Excellent communication, collaboration, and organizational skills.
• Required: Ability to work independently and in a fast-paced, matrixed environment.
• Required: Ability to travel up to 15%.

Skills

• Strong analytical and data interpretation abilities
• Collaborative cross-functional teamwork
• Effective scientific communication and regulatory writing

Education

• Ph.D., Pharm.D., or equivalent in Clinical Pharmacology, Pharmaceutical Sciences, or a related field.

Additional Requirements

• Travel up to 15%.
• On-site work location: San Diego, CA.