Director, Clinical Pharmacology and Pharmacokinetics

Role: Lead clinical pharmacology for Disc Medicine's hematologic disease programs, providing strategic and scientific oversight of clinical pharmacology studies. Responsibilities: design, execute, analyze, and interpret first-in-human, drug-drug interaction, biopharmaceutics, and ADME studies; manage internal teams and external CROs; contribute to regulatory interactions and submissions; collaborate cross-functionally with clinical operations, DMPK, biostatistics, and regulatory teams. Requirements: PhD in clinical pharmacology, pharmaceutical sciences, or related field; 10+ years industry experience in clinical pharmacology, with expertise in study design, PK/PD analysis, and regulatory guidance; prior experience with drug metabolism, biologics/large molecules, and regulatory agency interactions including IND submissions; proficiency in bioanalysis, data management, PK/PD modeling (WinNonlin, R, NONMEM, Monolix preferred). HighValue: hematologic therapeutic area, clinical-stage biopharma, biologics/modality experience, regulatory interactions, and bioanalytical/PK modeling skills. WorkSetup: hybrid, flexible remote and Watertown, MA location.