Director, Biology Group Lead

Role: Lead the biology organization for radiopharmaceutical discovery at RayzeBio, overseeing target discovery, validation, pharmacology, and candidate selection from target identification through IND-enabling studies. Responsibilities include developing and executing biology strategies, building and leading multidisciplinary teams, establishing target validation frameworks, and guiding mechanism-of-action and translational studies. The role also involves spearheading quantitative pharmacology and target engagement platforms, integrating biochemical, cellular, imaging, and dosimetry data, and supporting portfolio decisions. Collaboration spans across Radiochemistry, Medicinal Chemistry, Imaging, DMPK, Toxicology, and Clinical teams, with a focus on innovative oncology targets and radiopharmaceutical modalities. The position demands strategic leadership in target validation, assay development, and external scientific engagement, including academic and industry collaborations. Qualifications include a PhD in Cancer Biology, Pharmacology, or related fields, with 12+ years in biotech or pharma, proven leadership in oncology drug discovery, and experience advancing discovery programs. Preferred expertise encompasses radiopharmaceuticals, target biology relevant to radioligand therapies, and supporting early clinical development and IND filings. The role is based in San Diego, with a competitive salary range ($227,418 - $275,577) and benefits, including health coverage, time off, and work-life programs. It offers an opportunity to shape next-generation radiopharmaceutical therapies, lead innovative research, and contribute to transformative cancer treatments.