Director, Biology Group Lead
Bristol Myers Squibb
August 11, 2026
Remote friendly (San Diego, CA)
United States
Clinical Research and Development
Position Summary
The Director, Biology Group Lead will lead biology organization responsible for discovering and validating novel targets and advancing differentiated radiopharmaceutical candidates from target identification through IND-enabling studies.
Key Responsibilities
- Develop and execute biology strategy supporting discovery and development of novel radiopharmaceutical therapies.
- Build and lead a high-performing biology organization encompassing target identification, target validation, pharmacology, translational biology, and mechanism-of-action studies.
- Drive scientific strategy from target nomination through candidate selection and IND-enabling activities.
- Establish target validation frameworks incorporating biological relevance, target accessibility, internalization, biodistribution, imaging, dosimetry, and translational considerations unique to RPT.
- Lead quantitative pharmacology and assay development; establish biochemical and cell-based target engagement platforms (radioligand binding, flow cytometry, TR-FRET/HTRF, high-content imaging).
- Oversee quantitative characterization of drug–target interactions (affinity, binding kinetics, receptor occupancy, residence time, target density) using equilibrium and kinetic approaches.
- Integrate biochemical/cellular binding data with chemistry, imaging, and PK to support portfolio decisions; guide MOA and translational strategies.
- Lead target identification (genomics, transcriptomics, proteomics, spatial biology, literature mining) and target validation (in vitro/in vivo pharmacology).
- Serve on cross-functional project teams; drive milestones through IND candidate nomination; evaluate external opportunities (licensing, collaborations, acquisitions); leverage AI for prioritization.
- Recruit, mentor, and develop scientists; foster innovative, collaborative, rigorous culture.
- Build collaborations; represent at conferences/advisory boards; publish as appropriate.
Qualifications
- PhD in Cancer Biology, Pharmacology, Molecular Biology, Immunology, or related.
- 12+ years in biotechnology/pharma or similar industry experience.
- Demonstrated leadership in oncology drug discovery; track record advancing programs from target identification through development candidate selection.
- Significant experience leading multidisciplinary teams; strong understanding of oncology biology, pharmacology, and translational science.
- Experience integrating biology with medicinal chemistry, DMPK, imaging, toxicology, and clinical development.
- Excellent communication and organizational leadership; successful mentoring.
Preferred Qualifications
- Direct experience developing radiopharmaceutical therapies.
- Deep understanding of radioligand target biology (expression, internalization, retention, biodistribution, dosimetry, companion imaging).
- Experience supporting IND filings and early clinical development.
- Knowledge of theranostic strategies and biomarker-driven patient selection.
- Experience evaluating external technologies and business development opportunities; strong publication record.
Compensation / Benefits (explicitly listed)
- San Diego - RayzeBio - CA: $227,418 - $275,577.
- Health coverage (medical, pharmacy, dental, vision); wellbeing programs; 401(k), disability, life insurance, and other financial protection benefits.
- Paid time off (including flexible/unlimited PTO options depending on location/role) and additional eligibility-based time off.
Application Instructions
- If the role intrigues you but doesn’t perfectly line up, encouraged to apply anyway.
The Director, Biology Group Lead will lead biology organization responsible for discovering and validating novel targets and advancing differentiated radiopharmaceutical candidates from target identification through IND-enabling studies.
Key Responsibilities
- Develop and execute biology strategy supporting discovery and development of novel radiopharmaceutical therapies.
- Build and lead a high-performing biology organization encompassing target identification, target validation, pharmacology, translational biology, and mechanism-of-action studies.
- Drive scientific strategy from target nomination through candidate selection and IND-enabling activities.
- Establish target validation frameworks incorporating biological relevance, target accessibility, internalization, biodistribution, imaging, dosimetry, and translational considerations unique to RPT.
- Lead quantitative pharmacology and assay development; establish biochemical and cell-based target engagement platforms (radioligand binding, flow cytometry, TR-FRET/HTRF, high-content imaging).
- Oversee quantitative characterization of drug–target interactions (affinity, binding kinetics, receptor occupancy, residence time, target density) using equilibrium and kinetic approaches.
- Integrate biochemical/cellular binding data with chemistry, imaging, and PK to support portfolio decisions; guide MOA and translational strategies.
- Lead target identification (genomics, transcriptomics, proteomics, spatial biology, literature mining) and target validation (in vitro/in vivo pharmacology).
- Serve on cross-functional project teams; drive milestones through IND candidate nomination; evaluate external opportunities (licensing, collaborations, acquisitions); leverage AI for prioritization.
- Recruit, mentor, and develop scientists; foster innovative, collaborative, rigorous culture.
- Build collaborations; represent at conferences/advisory boards; publish as appropriate.
Qualifications
- PhD in Cancer Biology, Pharmacology, Molecular Biology, Immunology, or related.
- 12+ years in biotechnology/pharma or similar industry experience.
- Demonstrated leadership in oncology drug discovery; track record advancing programs from target identification through development candidate selection.
- Significant experience leading multidisciplinary teams; strong understanding of oncology biology, pharmacology, and translational science.
- Experience integrating biology with medicinal chemistry, DMPK, imaging, toxicology, and clinical development.
- Excellent communication and organizational leadership; successful mentoring.
Preferred Qualifications
- Direct experience developing radiopharmaceutical therapies.
- Deep understanding of radioligand target biology (expression, internalization, retention, biodistribution, dosimetry, companion imaging).
- Experience supporting IND filings and early clinical development.
- Knowledge of theranostic strategies and biomarker-driven patient selection.
- Experience evaluating external technologies and business development opportunities; strong publication record.
Compensation / Benefits (explicitly listed)
- San Diego - RayzeBio - CA: $227,418 - $275,577.
- Health coverage (medical, pharmacy, dental, vision); wellbeing programs; 401(k), disability, life insurance, and other financial protection benefits.
- Paid time off (including flexible/unlimited PTO options depending on location/role) and additional eligibility-based time off.
Application Instructions
- If the role intrigues you but doesn’t perfectly line up, encouraged to apply anyway.