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Director, Antibody Discovery

Flagship Pioneering
August 20, 2026
Full-time
Remote friendly (Cambridge, MA)
Worldwide
Clinical Research and Development
Role: Senior leadership position overseeing antibody discovery strategy and project delivery within a biopharma setting. Responsibilities include defining and leading antibody platform development, translating genomics screening outputs into drug discovery programs, providing expert advice on target feasibility and therapeutic design, and steering cross-functional teams from early conception to IND submission. The role involves managing external vendors, advocating for new technologies, and contributing to corporate strategies. Requirements: Proven experience in advancing protein therapeutics, expertise in structure-based antibody engineering, and proficiency with in silico, AI/ML approaches; extensive project leadership in pharma R&D, especially in antibody lead optimization through preclinical phases. Preferred: Experience in biotech startups, genomics-driven target discovery, broader protein sciences, and cellular assay design. The position demands senior-level experience with biologics development, especially in multispecifics, Fc engineering, and developability assessment. It involves collaboration with internal R&D teams and external partners, with a focus on innovation in antibody therapeutics. Location and travel details are not specified.