Director - ADME Project Leadership

Role: Lead ADME scientist within Lilly's Drug Disposition team, focusing on advancing pharmacokinetics and drug disposition for diverse modalities including small molecules, biologics, peptides, ADCs, siRNAs, and gene therapies. Responsibilities: design and interpret experimental studies using in vitro, in vivo, and in silico approaches; deliver integrated data packages for compound selection, portfolio decisions, and regulatory submissions; collaborate cross-functionally across Discovery and Development teams (e.g., Toxicology, Pharmacology, Chemistry, Regulatory); guide the development of ADME/DMPK capabilities; prepare regulatory documentation (IB, IND, NDA/BLA) and engage with regulators; mentor junior scientists and communicate the value of mechanistic ADME strategies internally and externally. Qualifications: Ph.D. in Pharmacokinetics, Pharmacology, Pharmaceutics, Biochemistry, or related with 6+ years of experience in drug metabolism/disposition or clinical pharmacology. Preferred skills: extensive small molecule experience, familiarity with biologics or other complex modalities, proficiency with modeling software (e.g., SimCYP, NONMEM), strong communication and collaboration skills. High-value biopharma specifics: emphasis on drug discovery and development, multiple modalities and therapeutic areas, regulatory interface, and expertise in pharmacokinetics and ADME sciences. Role based in Indianapolis; no explicit travel requirements specified.