Dir/Senior Director, Toxicology & Preclinical Pharmacology

Role: Senior/Director, Preclinical Pharmacology/Toxicology leading nonclinical studies for obesity and metabolic disease therapeutics, supporting peptide and small-molecule candidates from discovery through IND. Responsibilities: design, monitor, and interpret GLP and non-GLP pharmacology and toxicology studies; serve as scientific lead for CRO interactions; integrate pharmacology, PK, toxicokinetic, pathology, and biomarker data to inform development decisions; contribute to regulatory submissions (INDs, NDAs); collaborate with clinical teams for dose/risk assessment; mentor junior scientists; and support strategic planning for combination and next-gen therapies. Requirements: PhD/DVM/PharmD in Pharmacology, Toxicology, Physiology, or related; 10+ years in biotech/pharma; expertise in metabolic disease pharmacology, GLP toxicology, and support of IND-enabling programs; familiarity with ICH guidelines; understanding of peptide and small-molecule modalities. Knowledge: experience with GLP-1/GIP/amylin pathways, combination therapies, toxicology, DMPK, and regulatory interactions. HighValue: metabolic disease, obesity therapeutics, peptide/small-molecule development, IND support, GLP toxicology, cross-functional collaboration, external CRO oversight. WorkSetup: not specified.