Dermatologist Physician Scientist (Associate Director/Director) DUAL POSTING

Role Summary

Dermatologist Physician Scientist (Associate Director/Director) Dual Posting. This role can be based in Cambridge, MA USA, Basel, Switzerland, or London, United Kingdom.

Responsibilities

• Early clinical projects (Phase I / II, ‚ÄúDiscovery‚Äù): Develop strategies for the Translational Medicine component of drug development projects from research to late-stage transition in single or multiple indications, including indication expansion projects. Lead global project teams through phase I/IIa to drive implementation of the development strategy.
• Late-stage clinical projects (‚ÄúProfiling‚Äù): Act as a key leader in developing the Ph2-3 and post-approval profiling strategy for drug programs, representing TMDP on Global Project Team along with other TM line functions. Provide support for dose selection, study design and other clinical pharmacology matters throughout the development cycle. Oversee conduct and interpretation of studies prioritized to support pivotal trials.
• Drive analysis of studies and present results to relevant decision boards.
• Be responsible for writing TM portions of documents needed for regulatory submission through drug registration.
• Translational Research (TR; indication seeking, endpoint and biomarker development): In collaboration with Dermatology TM Head, BR Research scientists, other TM line functions develop strategies to identify initial or expansion indications. This may include methodology studies to identify and validate novel endpoints for early decision making in Phase IIa studies.
• Business Development and Licensing (BD&L; in-licensing and out licensing compounds): Participate in BD&L teams as the TM representative and in teams carrying out licensing of programs as subject matter expert for the disease indication, molecule, and clinical trial experience.
• General responsibilities: Responsible for clinical monitoring and integrated safety data review during and after the live phase of a study. Provide medical and scientific leadership and expertise to all line functions on the study team. Represent clinical Translational Medicine aspects to Health Authorities and other stakeholders. Oversee publication strategy for TM studies; lead writing of scientific publications; present study results externally where appropriate. Lead study-specific teams/clinical trial teams in partnership with other line functions and collaborate closely with other TM (especially clinical operations) and non-TM line functions to ensure operational excellence, continued urgency, and close attention to timelines, costs, and subject burden in balance with high scientific standards and innovation.

Qualifications

• This position will be located at the Cambridge, MA, London, UK or Basel, Switzerland site and will not have the ability to be located remotely. This position will require approximately 7% travel as defined by the business (domestic and/ or international).
• This is a dual posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience, and capabilities required to perform the role at the level the role has been offered (Associate Director / Director).
• Doctoral degree, MD required with clinical subspecialty training in dermatological diseases; Additional PhD/post-doctoral equivalent research and relevant Board certification preferred.
• Associate Director Level: 1-2 years of experience in a pharmaceutical/biotech company, CRO, or academic medical center, or related experience; Director Level: 5+ years of experience in a pharmaceutical/biotech company, CRO, or academic medical center, or related experience.
• Recognized medical expertise, as evidenced by publication of significant contributions to a field over time.
• Excellent written and oral communication/presentation skills.
• Independence: Able to work independently as outlined above, commensurate with the level of the role.
• Innovation: Seeks out new clinical discovery opportunities and approaches to accelerate programs.
• Leadership of Collaborations: Able to lead multidisciplinary teams in a matrix organization.
• Team player mentality and willingness to collaborate and interact with the other TMEs.

Skills

• Medical leadership and scientific expertise in translational medicine and dermatology
• Clinical pharmacology, study design, and regulatory submission experience
• Evidence-based decision making and data interpretation
• Strong collaboration and cross-functional leadership in matrix environments

Education

• MD with dermatology subspecialty training; PhD or post-doctoral research experience preferred