Clinical Pharmacology Director
Vertex Pharmaceuticals
August 30, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
General Summary:
The Clinical Pharmacology Director leads strategic, scientific, and operational aspects at a program level. Represents the department on cross-functional program teams; develops clinical pharmacology plans; supports management via program reviews and collaborative decision-making; supervises asset leads and provides career development; co-leads cross-functional efforts and leads department initiatives.
Key Duties and Responsibilities:
- Apply clinical quantitative pharmacology strategy to support the immunology portfolio.
- Guide metabolic, co-dosing, and drug-drug interaction issues with cross-functional colleagues.
- Co-lead/serve on cross-functional committees and/or lead departmental initiatives.
- Create protocol concepts and guide protocol start-up (site initiations, investigator meetings).
- Oversee and contribute to regulatory and safety documents; contribute to clinical pharmacology summary documents.
- Guide PK analyses; perform PK/PD or exploratory analyses and guide modeling/simulations.
- Provide mentorship; assist in recruitment and hiring.
Knowledge and Skills:
- Strong clinical pharmacology foundation (biologics, small molecules, and/or other modalities).
- Immunology/autoimmune disease experience.
- Quantitative clinical pharmacology execution; hands-on data analysis using Phoenix WinNonlin, R, and NONMEM.
- Interaction with health authorities.
- Leadership, critical thinking, and scientific/development judgment.
- Experience planning/executing Clinical Development Plans; conducting/supervising DDI, special population, and bioavailability studies.
- Experience with first-in-human, proof-of-concept, and registrational studies.
- Experience with clinical/regulatory documents (e.g., Investigator’s Brochure) and regulatory correspondence.
- Matrix/team experience.
Education and Experience:
- Ph.D. or Pharm D (or equivalent) in relevant fields + 10+ years post-doctoral experience, OR
- Master’s (or equivalent) + 15+ years relevant experience.
- Typically 3 years supervisory/management experience.
Compensation:
- Pay range: $200,000–$300,000.
- Eligible for annual bonus and annual equity awards.
The Clinical Pharmacology Director leads strategic, scientific, and operational aspects at a program level. Represents the department on cross-functional program teams; develops clinical pharmacology plans; supports management via program reviews and collaborative decision-making; supervises asset leads and provides career development; co-leads cross-functional efforts and leads department initiatives.
Key Duties and Responsibilities:
- Apply clinical quantitative pharmacology strategy to support the immunology portfolio.
- Guide metabolic, co-dosing, and drug-drug interaction issues with cross-functional colleagues.
- Co-lead/serve on cross-functional committees and/or lead departmental initiatives.
- Create protocol concepts and guide protocol start-up (site initiations, investigator meetings).
- Oversee and contribute to regulatory and safety documents; contribute to clinical pharmacology summary documents.
- Guide PK analyses; perform PK/PD or exploratory analyses and guide modeling/simulations.
- Provide mentorship; assist in recruitment and hiring.
Knowledge and Skills:
- Strong clinical pharmacology foundation (biologics, small molecules, and/or other modalities).
- Immunology/autoimmune disease experience.
- Quantitative clinical pharmacology execution; hands-on data analysis using Phoenix WinNonlin, R, and NONMEM.
- Interaction with health authorities.
- Leadership, critical thinking, and scientific/development judgment.
- Experience planning/executing Clinical Development Plans; conducting/supervising DDI, special population, and bioavailability studies.
- Experience with first-in-human, proof-of-concept, and registrational studies.
- Experience with clinical/regulatory documents (e.g., Investigator’s Brochure) and regulatory correspondence.
- Matrix/team experience.
Education and Experience:
- Ph.D. or Pharm D (or equivalent) in relevant fields + 10+ years post-doctoral experience, OR
- Master’s (or equivalent) + 15+ years relevant experience.
- Typically 3 years supervisory/management experience.
Compensation:
- Pay range: $200,000–$300,000.
- Eligible for annual bonus and annual equity awards.