Clinical Pharmacology Director
Vertex Pharmaceuticals
August 09, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
General Summary:
The Clinical Pharmacology Director leads strategic, scientific and operational aspects at a program level. Represents the department on cross-functional program teams; develops clinical pharmacology plans; supports departmental management through program reviews; supervises asset leads and provides career development; co-leads cross-functional efforts and leads department initiatives.
Key Duties And Responsibilities:
- Apply clinical quantitative pharmacology strategy to support the immunology portfolio.
- Guide metabolic, co-dosing and drug-drug interaction issues in collaboration with cross-functional colleagues.
- Co-lead or serve on cross-functional committees and/or contribute to or lead departmental initiatives.
- Create protocol concepts and guide protocol start-up (site initiations, investigator meetings).
- Oversee and contribute to regulatory and safety documents; contribute to clinical pharmacology summary documents.
- Guide PK analyses; perform PK/PD or exploratory analyses and guide PK/PD modeling or simulations.
- Provide mentorship; assist in recruitment and hiring.
Knowledge And Skills (Qualifications):
- Strong foundational knowledge in clinical pharmacology of biologics, small molecules, and/or other drug modalities.
- Immunology/Autoimmune disease therapeutic area or relevant disease knowledge.
- Quantitative clinical pharmacology execution and data analysis using Phoenix WinNonlin, R, and NONMEM.
- Interaction with health authorities.
- Leadership, critical thinking, scientific and development judgment.
- Experience planning/executing Clinical Development Plans; conducting/supervising clinical studies (DDI, special populations, bioavailability).
- Experience with first-in-human, proof-of-concept, and registrational studies.
- Experience contributing to clinical/regulatory documents (e.g., Investigator’s Brochure, regulatory correspondence).
- Experience working in matrix environments.
Education And Experience:
- Ph.D. or Pharm D (or equivalent) in pharmacokinetics/pharmacometrcs/clinical pharmacology/translational development + 10+ years post-doctoral experience, or
- Masters (or equivalent) + 15+ years relevant experience.
- Typically 3 years supervisory/management experience.
The Clinical Pharmacology Director leads strategic, scientific and operational aspects at a program level. Represents the department on cross-functional program teams; develops clinical pharmacology plans; supports departmental management through program reviews; supervises asset leads and provides career development; co-leads cross-functional efforts and leads department initiatives.
Key Duties And Responsibilities:
- Apply clinical quantitative pharmacology strategy to support the immunology portfolio.
- Guide metabolic, co-dosing and drug-drug interaction issues in collaboration with cross-functional colleagues.
- Co-lead or serve on cross-functional committees and/or contribute to or lead departmental initiatives.
- Create protocol concepts and guide protocol start-up (site initiations, investigator meetings).
- Oversee and contribute to regulatory and safety documents; contribute to clinical pharmacology summary documents.
- Guide PK analyses; perform PK/PD or exploratory analyses and guide PK/PD modeling or simulations.
- Provide mentorship; assist in recruitment and hiring.
Knowledge And Skills (Qualifications):
- Strong foundational knowledge in clinical pharmacology of biologics, small molecules, and/or other drug modalities.
- Immunology/Autoimmune disease therapeutic area or relevant disease knowledge.
- Quantitative clinical pharmacology execution and data analysis using Phoenix WinNonlin, R, and NONMEM.
- Interaction with health authorities.
- Leadership, critical thinking, scientific and development judgment.
- Experience planning/executing Clinical Development Plans; conducting/supervising clinical studies (DDI, special populations, bioavailability).
- Experience with first-in-human, proof-of-concept, and registrational studies.
- Experience contributing to clinical/regulatory documents (e.g., Investigator’s Brochure, regulatory correspondence).
- Experience working in matrix environments.
Education And Experience:
- Ph.D. or Pharm D (or equivalent) in pharmacokinetics/pharmacometrcs/clinical pharmacology/translational development + 10+ years post-doctoral experience, or
- Masters (or equivalent) + 15+ years relevant experience.
- Typically 3 years supervisory/management experience.