Clinical Development Senior Medical Director - Vascular
GSK
August 12, 2026
Remote friendly (Collegeville, PA)
United States
Clinical Research and Development
Position Summary
You will lead clinical development medical activities for vascular programmes across early and later phase studies. You will work closely with colleagues in clinical operations, translational science, regulatory, safety, and commercial teams.
What you’ll do
- Lead formulation of translational and clinical plans and study designs; develop sections of core regulatory documents.
- Generate data/evidence to determine target efficacy, safety, differentiation, and route to value.
- Define and deliver clinical pillars (timelines and endpoints, including pharmacology, mechanism, and clinical efficacy); enable go/no-go criteria.
- Establish and maintain relationships with counterparts across biology, translational sciences, commercial, regulatory, clinical operations, market access, medical affairs, and statistics.
- Provide support/oversight of evidence generation strategy to ensure patient safety and on-time, in-full delivery.
- Lead design of clinical development plans, study protocols, and documents across all phases.
- Bring clinical expertise to regulatory interactions and documents.
- Provide medical monitoring and safety oversight with pharmacovigilance physician; accountable for medical governance.
- Lead clinical matrix team (CMT); serve as clinical point of contact; lead end-to-end clinical development strategy.
- Lead clinical evaluation of business development opportunities.
- Oversee cross-disciplinary inputs for clinical components of the medicine profile.
Required Qualifications
- Medical degree.
- Board registration/certification/eligibility in cardiovascular medicine/vascular medicine or related specialty.
- Minimum 5 years’ experience in clinical research and development.
- Translational studies experience (human translational data; preclinical experiments in relevant models).
- Robust cardiovascular research knowledge (priorities, public health needs, competitor landscape, practice trends, guideline evolution).
- Experience with global regulatory agencies and global clinical trials.
- Knowledge of regulatory requirements, GCP, and ethical guidelines.
- Ability to collaborate in cross-functional/matrix environments to design and execute trials to regulatory standards.
Preferred Qualifications
- PhD in addition to medical degree.
- Experience contributing to IND/CTA, NDA, BLA, or MAA submissions.
Skills
Clinical Development; Communication; Drug Regulatory Affairs; Evidence Based Decision Making; GCP; Influencing Without Authority; Learning Agility; People Management; Project Management; Scientific Presentations; Strategic Thinking.
How to apply
Apply with your CV and a short note describing a clinical development or safety activity you led and the impact delivered.
You will lead clinical development medical activities for vascular programmes across early and later phase studies. You will work closely with colleagues in clinical operations, translational science, regulatory, safety, and commercial teams.
What you’ll do
- Lead formulation of translational and clinical plans and study designs; develop sections of core regulatory documents.
- Generate data/evidence to determine target efficacy, safety, differentiation, and route to value.
- Define and deliver clinical pillars (timelines and endpoints, including pharmacology, mechanism, and clinical efficacy); enable go/no-go criteria.
- Establish and maintain relationships with counterparts across biology, translational sciences, commercial, regulatory, clinical operations, market access, medical affairs, and statistics.
- Provide support/oversight of evidence generation strategy to ensure patient safety and on-time, in-full delivery.
- Lead design of clinical development plans, study protocols, and documents across all phases.
- Bring clinical expertise to regulatory interactions and documents.
- Provide medical monitoring and safety oversight with pharmacovigilance physician; accountable for medical governance.
- Lead clinical matrix team (CMT); serve as clinical point of contact; lead end-to-end clinical development strategy.
- Lead clinical evaluation of business development opportunities.
- Oversee cross-disciplinary inputs for clinical components of the medicine profile.
Required Qualifications
- Medical degree.
- Board registration/certification/eligibility in cardiovascular medicine/vascular medicine or related specialty.
- Minimum 5 years’ experience in clinical research and development.
- Translational studies experience (human translational data; preclinical experiments in relevant models).
- Robust cardiovascular research knowledge (priorities, public health needs, competitor landscape, practice trends, guideline evolution).
- Experience with global regulatory agencies and global clinical trials.
- Knowledge of regulatory requirements, GCP, and ethical guidelines.
- Ability to collaborate in cross-functional/matrix environments to design and execute trials to regulatory standards.
Preferred Qualifications
- PhD in addition to medical degree.
- Experience contributing to IND/CTA, NDA, BLA, or MAA submissions.
Skills
Clinical Development; Communication; Drug Regulatory Affairs; Evidence Based Decision Making; GCP; Influencing Without Authority; Learning Agility; People Management; Project Management; Scientific Presentations; Strategic Thinking.
How to apply
Apply with your CV and a short note describing a clinical development or safety activity you led and the impact delivered.