Clinical Development Leader, Lifecycle Management
Praxis Precision Medicines, Inc.
August 20, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
Primary Responsibilities
- Lifecycle strategy: Identify and drive opportunities to expand the impact of late-stage and marketed assets, including new indications, label expansion, and formulation opportunities.
- Early development: Lead first-in-human and dose-escalation studies, applying PK/PD and emerging clinical data to dose selection, decision rules, and next-stage development.
- Clinical entry: Drive the clinical strategy and content for IND-enabling submissions and the decisions required to move programs into human studies.
- Pipeline-wide leadership: Work across mechanisms, indications, and phases to make sound clinical development decisions.
- Data-driven decisions: Interpret emerging clinical and scientific data, identify what matters, and make timely calls when information is incomplete.
- Cross-functional and external leadership: Lead teams across clinical operations, biostatistics, regulatory, safety, translational sciences, and other disciplines; represent the company with investigators, KOLs, health authorities, and partners.
Qualifications
- Advanced scientific degree (MD, PharmD, PhD, or equivalent) required.
- Track record of clinical trials, programs, submissions, or major development decisions personally led.
- Regulatory submission ownership: clinical content of IND/CTA/NDA/MAA filings, briefing books, and health authority interactions.
- Strong judgment to make timely calls on emerging data with incomplete information; ability to know what to escalate and when.
- Comfort in a dynamic environment with shifting priorities and evolving scope.
Benefits
- Annualized base salary: $280,000–$350,000 USD.
- Benefits include 99% premium paid for medical/dental/vision; company-paid life insurance, AD&D, disability; voluntary plans; 401(k) match up to 6%; long-term stock incentives and ESPP; discretionary quarterly bonus; wellness benefit; generous PTO; paid holidays and company-wide shutdowns.
- Lifecycle strategy: Identify and drive opportunities to expand the impact of late-stage and marketed assets, including new indications, label expansion, and formulation opportunities.
- Early development: Lead first-in-human and dose-escalation studies, applying PK/PD and emerging clinical data to dose selection, decision rules, and next-stage development.
- Clinical entry: Drive the clinical strategy and content for IND-enabling submissions and the decisions required to move programs into human studies.
- Pipeline-wide leadership: Work across mechanisms, indications, and phases to make sound clinical development decisions.
- Data-driven decisions: Interpret emerging clinical and scientific data, identify what matters, and make timely calls when information is incomplete.
- Cross-functional and external leadership: Lead teams across clinical operations, biostatistics, regulatory, safety, translational sciences, and other disciplines; represent the company with investigators, KOLs, health authorities, and partners.
Qualifications
- Advanced scientific degree (MD, PharmD, PhD, or equivalent) required.
- Track record of clinical trials, programs, submissions, or major development decisions personally led.
- Regulatory submission ownership: clinical content of IND/CTA/NDA/MAA filings, briefing books, and health authority interactions.
- Strong judgment to make timely calls on emerging data with incomplete information; ability to know what to escalate and when.
- Comfort in a dynamic environment with shifting priorities and evolving scope.
Benefits
- Annualized base salary: $280,000–$350,000 USD.
- Benefits include 99% premium paid for medical/dental/vision; company-paid life insurance, AD&D, disability; voluntary plans; 401(k) match up to 6%; long-term stock incentives and ESPP; discretionary quarterly bonus; wellness benefit; generous PTO; paid holidays and company-wide shutdowns.