Clinical Development Associate Medical Director- Pain
Vertex Pharmaceuticals
August 08, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
General Summary:
The Clinical Development Associate Medical Director will serve as the Medical Lead for clinical trials, working with cross-functional teams on trial strategy, design, execution, and reporting. In addition to oversight and accountability for the study as a whole, this role serves as the internal primary Medical Monitor accountable for monitoring the safety of enrolled subjects and ensuring scientific integrity. The incumbent may participate in other projects to support the clinical development program.
Key Duties And Responsibilities:
- Participate in development of Study Protocols, Investigator's Brochures, Clinical Development Plans, and other key documents with minimal guidance
- Serve on cross-functional Study Execution Teams (SET) to achieve efficient, high-quality study execution
- Prepare regulatory documents for submissions (IND/CTA clinical sections, IND safety/annual reports, responses to authorities and Ethics Committees/IRBs)
- Provide scientific/clinical input to study documents and analysis plans (informed consent forms, research forms, statistical and clinical pharmacology analysis plans, clinical study reports)
- Liaison between Clinical Development and internal groups (e.g., Regulatory Affairs, Clinical Development Execution)
- Represent Vertex to outside medical personnel for protocol development, study conduct, and external reporting of results
- Perform other duties as assigned related to Clinical Development
Knowledge And Skills:
- Strong oral and written communication; collaborative in fast-paced matrix environments
- Global clinical research experience and experience interacting with regulatory authorities (plus)
- Familiarity with data analysis, biostatistics, pharmacology/pharmacokinetics, GCP, study design, ethics/IRB review, manuscript/abstract/poster and oral presentation preparation, and drug/device clinical development
- Board certification/eligibility and clinical training in a relevant medical specialty (highly desired)
Education And Experience:
- MD, DO, or equivalent ex-US medical degree
- Typically 8 years of basic or clinical research experience (academic or industry) or equivalent combination of education and experience
Compensation And Benefits:
- Pay range: $204,000 - $306,000
- Eligible for annual bonus and annual equity awards; some roles may be eligible for overtime pay
- Total Rewards benefits include medical, dental, vision, paid time off (including week-long summer and winter shutdown), educational assistance (student loan repayment), commuting subsidy, matching charitable donations, 401(k)
Flex Designation:
- Hybrid-eligible or on-site eligible (hybrid: up to two remote days/week; on-site: five days/week with ad hoc flexibility)
The Clinical Development Associate Medical Director will serve as the Medical Lead for clinical trials, working with cross-functional teams on trial strategy, design, execution, and reporting. In addition to oversight and accountability for the study as a whole, this role serves as the internal primary Medical Monitor accountable for monitoring the safety of enrolled subjects and ensuring scientific integrity. The incumbent may participate in other projects to support the clinical development program.
Key Duties And Responsibilities:
- Participate in development of Study Protocols, Investigator's Brochures, Clinical Development Plans, and other key documents with minimal guidance
- Serve on cross-functional Study Execution Teams (SET) to achieve efficient, high-quality study execution
- Prepare regulatory documents for submissions (IND/CTA clinical sections, IND safety/annual reports, responses to authorities and Ethics Committees/IRBs)
- Provide scientific/clinical input to study documents and analysis plans (informed consent forms, research forms, statistical and clinical pharmacology analysis plans, clinical study reports)
- Liaison between Clinical Development and internal groups (e.g., Regulatory Affairs, Clinical Development Execution)
- Represent Vertex to outside medical personnel for protocol development, study conduct, and external reporting of results
- Perform other duties as assigned related to Clinical Development
Knowledge And Skills:
- Strong oral and written communication; collaborative in fast-paced matrix environments
- Global clinical research experience and experience interacting with regulatory authorities (plus)
- Familiarity with data analysis, biostatistics, pharmacology/pharmacokinetics, GCP, study design, ethics/IRB review, manuscript/abstract/poster and oral presentation preparation, and drug/device clinical development
- Board certification/eligibility and clinical training in a relevant medical specialty (highly desired)
Education And Experience:
- MD, DO, or equivalent ex-US medical degree
- Typically 8 years of basic or clinical research experience (academic or industry) or equivalent combination of education and experience
Compensation And Benefits:
- Pay range: $204,000 - $306,000
- Eligible for annual bonus and annual equity awards; some roles may be eligible for overtime pay
- Total Rewards benefits include medical, dental, vision, paid time off (including week-long summer and winter shutdown), educational assistance (student loan repayment), commuting subsidy, matching charitable donations, 401(k)
Flex Designation:
- Hybrid-eligible or on-site eligible (hybrid: up to two remote days/week; on-site: five days/week with ad hoc flexibility)