Clinical Biomarker Lead

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

• Lead end-to-end execution of the clinical biomarker strategy to support Janux’s oncology and autoimmune clinical programs
• Organize and maintain clinical biomarker and bioanalytical datasets and individual patient profiles for clinical programs.
• Perform high throughput data analytics of, translational, and clinical datasets to identify and validate potential biomarkers of response/resistance to TRACTr, TRACIr, and/or ARM treatments.
• Integrate functional biological readouts with patient’s clinicopathological features to contribute to patient selection strategies for clinical programs.
• Collaborate with Biomarker and clinical operation teams to ensure end-to-end sample tracking and maintain oversight on all sample related timelines including subsequent data collection and distribution.
• Manage multiple specialty vendor labs and maintain strong oversight on deliverables (proposals, timelines, experimental design, data analyses and reporting).
• Prepare and present data. Collaborate with internal Clinical Science and Research/ Immunology   teams to evaluate data analytic approaches and ensure meaningful insights in the delivery. Perform in-depth scientific literature review to help address critical questions relating to target biology, clinical relevance, and associated assays.
• Work cross-functionally with Research, Clinical and CMC teams to drive scientific programs and deliver critical insights to help inform decision-making across the portfolio. 

EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES

• Ph.D. in Immunology, Clinical/Health Sciences, Bioinformatics, or related scientific discipline with 4+ years of experience, preferably in an industry setting, with an emphasis in clinical biomarker analysis or translational medicine.
• Strong understanding and experience working in immuno-oncology and/or solid tumor oncology with hands-on experience in designing, developing, and interpreting clinical biomarker datasets.
• Competence with data analysis tools (Excel, GraphPad). Proficiency in data handling and visualization with R or Python is preferred.
• Demonstrated ability to create impactful data visualization outputs and present meaningful insights.
• Experience working with EDC systems and data listings is highly preferred.
• Experience with Good Clinical Practice (GCP) principles and studies transitioning into clinical trials.   
• Experience working with external CROs (due diligence, proposals, oversight, project management, data analyses, and reporting) is highly preferred.
• Strong analytical and critical thinking skills with the ability to work in a fast-paced environment. Excellent written and oral communication skills.