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The Business Development Transactions, Sr Director will be responsible for leading/supporting cross-functional technical and corporate due diligence efforts and the negotiation and execution of a range of business development transactions, including collaborations, licenses, financings, mergers and acquisitions, all aimed at helping Vertex achieve its strategic objectives and create sustained revenue and earnings growth. This role is Hybrid-Eligible or On-Site Eligible, with remote work up to two days per week or on-site five days per week with ad hoc flexibility.