Biostatistics Associate Director (HYBRID)
Vertex Pharmaceuticals
August 07, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
General Summary:
- Biostatistics Associate Director performs sophisticated scientific statistical analyses in support of Global Medicines Development and Affairs with minimal guidance, making independent strategic and technical contributions.
Key Duties and Responsibilities:
- Conduct scientific/operational statistical work for multiple clinical trials, observational studies, and RWD investigations.
- Lead biostatistics projects/components, including work allocation and review.
- Present to Peer Protocol Review Committee (PPRC) or other internal senior review boards.
- Provide specialized technical guidance in cross-functional teams.
- Author Statistical Analysis Plans (SAPs) including TFL shells; develop xFDR plan, KRM, and DDP.
- Collaborate with statistical programming to ensure timely, high-quality TFL delivery.
- Contribute to CSRs; author/co-author methodological or study-related publications and posters.
- Provide input into programming specifications and review.
- Contribute to interactions with regulators, payers, and review boards.
- Determine/implement design and analysis methods; participate in SRF discussions.
- Independently tackle new/complex issues; conceptualize alternative approaches.
Knowledge/Skills (Qualifications):
- Ph.D. in Statistics or Biostatistics.
- Typically 7 years post-Ph.D. experience (or equivalent education/experience).
- In-depth competence with SAS and R.
- In-depth understanding of advanced statistical methods in drug development.
- Critical thinking, excellent written/verbal communication; strong teamwork.
- Some staff management experience typical.
- NDA/MAA experience; direct dealings with USA/European regulators.
Pay Range:
- $174,800 - $262,200. Eligible for annual bonus and annual equity awards.
- Biostatistics Associate Director performs sophisticated scientific statistical analyses in support of Global Medicines Development and Affairs with minimal guidance, making independent strategic and technical contributions.
Key Duties and Responsibilities:
- Conduct scientific/operational statistical work for multiple clinical trials, observational studies, and RWD investigations.
- Lead biostatistics projects/components, including work allocation and review.
- Present to Peer Protocol Review Committee (PPRC) or other internal senior review boards.
- Provide specialized technical guidance in cross-functional teams.
- Author Statistical Analysis Plans (SAPs) including TFL shells; develop xFDR plan, KRM, and DDP.
- Collaborate with statistical programming to ensure timely, high-quality TFL delivery.
- Contribute to CSRs; author/co-author methodological or study-related publications and posters.
- Provide input into programming specifications and review.
- Contribute to interactions with regulators, payers, and review boards.
- Determine/implement design and analysis methods; participate in SRF discussions.
- Independently tackle new/complex issues; conceptualize alternative approaches.
Knowledge/Skills (Qualifications):
- Ph.D. in Statistics or Biostatistics.
- Typically 7 years post-Ph.D. experience (or equivalent education/experience).
- In-depth competence with SAS and R.
- In-depth understanding of advanced statistical methods in drug development.
- Critical thinking, excellent written/verbal communication; strong teamwork.
- Some staff management experience typical.
- NDA/MAA experience; direct dealings with USA/European regulators.
Pay Range:
- $174,800 - $262,200. Eligible for annual bonus and annual equity awards.