Biology - Imaging R&D

Role Summary

Eli Lilly and Company (Lilly) Imaging Research and Development provides technical expertise for molecular and anatomical imaging to Lilly Research Laboratories. The Biologist will provide histopathology support by assisting in human tissue labeling to establish well-characterized tissue panels for compound screening and pathophysiological evaluation of target expression towards the discovery of new PET tracers for evaluation as development candidates.

Responsibilities

• Design, develop, and execute human brain tissue characterization protocols (sample preparation and cryosectioning, staining, immunohistochemistry and autoradiography) for neuroscience research and imaging biomarker projects.
• Assist in organization of tissue staining data from various research projects
• Conduct and design radioligand binding assays such as autoradiography.
• Implement digital pathology tools compatible with whole slide imaging scanner, autoradiography and confocal microscopy.

Qualifications

• Required: Master of science degree, preferentially in Neuroscience with a minimum of 1 year experience in PET tracer discovery.
• Preferred: Proficiency in immunohistochemistry, including immunofluorescence, automated histology equipment, spatial omics platform, gene silencing knowledge, and morphometry image analysis software (Visiopharm).
• Provide strategic and technical expertise on the design and optimization of protein and transcript target detection.
• Develop morphometric quantitative analysis methods using AI/ML software for target mapping in human samples
• Experience in rodent and human tissue preparation and handling
• Evaluation of small molecules and biologicals
• Ensure good laboratory practice for data documentation as well as communicate research findings and recommendations to internal and external stakeholders through written reports, oral presentations and scientific communications.
• In-depth knowledge of rodent and human neuroanatomy
• Understanding of neuropathological hallmarks scoring
• Use of real-time autoradiography is preferred
• Ability to be pro-active, flexible, and capable of independent trouble shooting and problem solving. Work within a team-oriented lab environment and work within cross-functional project teams
• Participate in scientific conferences and workshops to continue education/professional development
• Good organizational and time-management skills
• Excellent written and verbal communication skills

Skills

• Immunohistochemistry and immunofluorescence
• Automated histology equipment
• Spatial omics platforms
• Morphometry image analysis software (e.g., VisioPharm)
• Radioligand binding assays and autoradiography
• Digital pathology tools and whole slide imaging
• AI/ML-based morphometric analysis
• Neuroanatomy knowledge (rodent and human)
• Data documentation and scientific communication
• Laboratory best practices and compliance

Education

• Master of Science degree, preferably in Neuroscience