Associate Scientist - Protein Biochemistry (siRNA Therapeutics, Lipid Nanoparticles)
Regeneron
2 hours ago
Remote friendly (Tarrytown, NY)
United States
Clinical Research and Development
Responsibilities:
- Provide in-depth characterization of nucleic acid therapeutics and Lipid Nanoparticles (LNP).
- Develop analytical methods and conduct biochemical and biophysical characterization experiments to elucidate quality attributes of gene therapy candidates.
- Support basic research; adapt and/or optimize methods described in the literature.
- Conduct time-sensitive biochemical and extended characterization of siRNAs to meet regulatory timelines.
- Provide input on experimental design and suggest method adaptations for program needs and attributes of colloidal systems.
- Develop advanced technologies evaluating purity and/or thermodynamic and hydrodynamic interactions of siRNAs, mRNAs, CRISPR gRNA, and LNP-nucleic acid complexes.
- Support forced degradation studies assessing environmental stressors and their impact on stability of siRNA, LNPs, and their cargos.
- Document experiments/results in electronic laboratory notebooks; present work at meetings; contribute to protocols, method development reports, regulatory submission sections, and peer-reviewed publications.
- Maintain instruments, troubleshoot experimental problems, and order/maintain supplies.
Qualifications:
- BS or MS in Biophysics, Biochemistry, Chemistry, Chemical Engineering, or related field.
- Minimum experience: 0–2 years with an MS, or 2+ years with a BS.
- Fundamental understanding of practical biophysical chemistry of macromolecules in solution.
- Basic knowledge of oligonucleotide properties, lipid biochemistry, and gene editing therapeutics.
Required/Preferred Skills:
- Good laboratory practice: sample preparation, concentration calculations, documentation, and cleanliness.
- Basic practical experience with automated chromatography (FPLC, H/UPLC), spectroscopy (UV-Vis, fluorescence, FTIR, CD) and/or multi-angle/dynamic light scattering (MALS/DLS).
- Bonus: experience with mass spectrometry (MS), NMR, ELSD/CAD, charge-based methods, and/or advanced imaging.
- Excellent oral and written communication skills.
- Strong initiative and urgency for challenging tasks.
- Ability and desire to learn new technologies; work independently and collaboratively.
- Primarily on-site with partially remote (hybrid) schedule.
Benefits:
- Health and wellness programs (medical, dental, vision, life, disability), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave).
Application Instructions:
- Apply now.
- Provide in-depth characterization of nucleic acid therapeutics and Lipid Nanoparticles (LNP).
- Develop analytical methods and conduct biochemical and biophysical characterization experiments to elucidate quality attributes of gene therapy candidates.
- Support basic research; adapt and/or optimize methods described in the literature.
- Conduct time-sensitive biochemical and extended characterization of siRNAs to meet regulatory timelines.
- Provide input on experimental design and suggest method adaptations for program needs and attributes of colloidal systems.
- Develop advanced technologies evaluating purity and/or thermodynamic and hydrodynamic interactions of siRNAs, mRNAs, CRISPR gRNA, and LNP-nucleic acid complexes.
- Support forced degradation studies assessing environmental stressors and their impact on stability of siRNA, LNPs, and their cargos.
- Document experiments/results in electronic laboratory notebooks; present work at meetings; contribute to protocols, method development reports, regulatory submission sections, and peer-reviewed publications.
- Maintain instruments, troubleshoot experimental problems, and order/maintain supplies.
Qualifications:
- BS or MS in Biophysics, Biochemistry, Chemistry, Chemical Engineering, or related field.
- Minimum experience: 0–2 years with an MS, or 2+ years with a BS.
- Fundamental understanding of practical biophysical chemistry of macromolecules in solution.
- Basic knowledge of oligonucleotide properties, lipid biochemistry, and gene editing therapeutics.
Required/Preferred Skills:
- Good laboratory practice: sample preparation, concentration calculations, documentation, and cleanliness.
- Basic practical experience with automated chromatography (FPLC, H/UPLC), spectroscopy (UV-Vis, fluorescence, FTIR, CD) and/or multi-angle/dynamic light scattering (MALS/DLS).
- Bonus: experience with mass spectrometry (MS), NMR, ELSD/CAD, charge-based methods, and/or advanced imaging.
- Excellent oral and written communication skills.
- Strong initiative and urgency for challenging tasks.
- Ability and desire to learn new technologies; work independently and collaboratively.
- Primarily on-site with partially remote (hybrid) schedule.
Benefits:
- Health and wellness programs (medical, dental, vision, life, disability), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave).
Application Instructions:
- Apply now.