Associate Scientist - Process Development
Eli Lilly and Company
8 days ago
Remote friendly (Boston, MA)
United States
Operations
Key Responsibilities
- Lead development, optimization, and scale-up of downstream purification workflows for viral vectors.
- Design and implement purification strategies using iodixanol and CsCl density gradient ultracentrifugation, affinity chromatography, ion-exchange chromatography (AEX/CEX), membrane chromatography, and polishing operations.
- Lead AKTA-based chromatography workflow development and process intensification initiatives.
- Develop scalable downstream platform approaches to support rapid material generation and process consistency across programs.
- Independently design experiments, analyze data, interpret results, and present technical conclusions to multi-functional teams and leadership.
- Drive troubleshooting, process characterization, and process robustness studies.
- Collaborate with upstream, analytical, manufacturing, and external partners to support program deliverables and timelines.
- Support technology transfer, process documentation, and development reports.
- Lead development and optimization of TFF/UFDF workflows for concentration, buffer exchange, formulation, and process scalability.
- Mentor junior scientists/engineers and provide technical guidance.
- Contribute to implementation of new purification technologies, automation tools, and continuous process improvements.
- Ensure compliance with safety, documentation, and quality standards.
Basic Qualifications
- Master’s degree in biology, biochemistry, chemical engineering, biotechnology, or related field.
- 8+ years of downstream process development experience in industry.
- Authorization to work in the United States on a full-time basis; Lilly will not sponsor visas.
Additional Skills/Preferences
- CsCl and iodixanol ultracentrifugation; affinity and ion-exchange chromatography; TFF/UFDF (concentration, diafiltration, formulation).
- AKTA systems and Unicorn software.
- Process scale-up, platform development, and purification characterization; analytical methods for performance/quality.
- AAV downstream process development and capsid enrichment; automated chromatography and process intensification.
- Technology transfer/manufacturing readiness; GMP development environments and regulatory expectations.
Benefits (if applicable)
- Company bonus; comprehensive benefits including 401(k), medical/dental/vision, flexible benefits, life insurance, time off/leave, and well-being benefits.
Compensation
- Anticipated wage: $71,250–$187,000.
Application instructions
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation.
- Lead development, optimization, and scale-up of downstream purification workflows for viral vectors.
- Design and implement purification strategies using iodixanol and CsCl density gradient ultracentrifugation, affinity chromatography, ion-exchange chromatography (AEX/CEX), membrane chromatography, and polishing operations.
- Lead AKTA-based chromatography workflow development and process intensification initiatives.
- Develop scalable downstream platform approaches to support rapid material generation and process consistency across programs.
- Independently design experiments, analyze data, interpret results, and present technical conclusions to multi-functional teams and leadership.
- Drive troubleshooting, process characterization, and process robustness studies.
- Collaborate with upstream, analytical, manufacturing, and external partners to support program deliverables and timelines.
- Support technology transfer, process documentation, and development reports.
- Lead development and optimization of TFF/UFDF workflows for concentration, buffer exchange, formulation, and process scalability.
- Mentor junior scientists/engineers and provide technical guidance.
- Contribute to implementation of new purification technologies, automation tools, and continuous process improvements.
- Ensure compliance with safety, documentation, and quality standards.
Basic Qualifications
- Master’s degree in biology, biochemistry, chemical engineering, biotechnology, or related field.
- 8+ years of downstream process development experience in industry.
- Authorization to work in the United States on a full-time basis; Lilly will not sponsor visas.
Additional Skills/Preferences
- CsCl and iodixanol ultracentrifugation; affinity and ion-exchange chromatography; TFF/UFDF (concentration, diafiltration, formulation).
- AKTA systems and Unicorn software.
- Process scale-up, platform development, and purification characterization; analytical methods for performance/quality.
- AAV downstream process development and capsid enrichment; automated chromatography and process intensification.
- Technology transfer/manufacturing readiness; GMP development environments and regulatory expectations.
Benefits (if applicable)
- Company bonus; comprehensive benefits including 401(k), medical/dental/vision, flexible benefits, life insurance, time off/leave, and well-being benefits.
Compensation
- Anticipated wage: $71,250–$187,000.
Application instructions
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation.