Associate Scientist, Oligonucleotide Chemistry & Delivery
Denali Therapeutics
August 17, 2026
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development
Key Accountabilities/Core Job Responsibilities
- Design, synthesize, purify, and characterize oligonucleotide therapeutics, including siRNA/ASOs, for early discovery OTV programs.
- Design and generate antibody-oligonucleotide conjugates for targeted delivery of siRNA/ASOs using bioconjugation technologies.
- Support high-throughput and mid-scale oligonucleotide synthesis, including evaluating novel chemistries, modifications, and workflow innovations.
- Develop, refine, and troubleshoot oligonucleotide synthesis, bioconjugation, purification, and analytical methods.
- Use analytical technologies (UV–Vis spectrophotometry, HPLC, mass spectrometry, MALS, and other techniques) to analyze, purify, quantify, and characterize oligonucleotides and bioconjugates.
- Interpret in vitro and in vivo data to generate structure-activity relationships (SAR) to guide iterative experimentation and preclinical candidate nomination.
- Collaborate with cross-functional teams (Biology, Protein Sciences, DMPK) to advance drug discovery objectives.
- Maintain accurate experimental documentation in electronic lab notebooks.
- Communicate results and recommendations in team and cross-functional meetings.
Qualifications/Skills
- 2+ years related experience with a Bachelor’s degree, or 1+ years with a Master’s degree.
- Hands-on experience in oligonucleotide synthesis, purification, and characterization (siRNA/ASOs).
- Experience with bioconjugation chemistry and analytical characterization of oligonucleotide conjugates.
- Ability to develop/troubleshoot workflows and independently design, execute, and interpret experiments.
- Excellent written and verbal communication skills; collaborative, multidisciplinary mindset.
Benefits (if listed)
- Competitive total rewards package including 401k, healthcare coverage, and ESPP.
Application Instructions
- Learn more at https://www.denalitherapeutics.com/careers
- Design, synthesize, purify, and characterize oligonucleotide therapeutics, including siRNA/ASOs, for early discovery OTV programs.
- Design and generate antibody-oligonucleotide conjugates for targeted delivery of siRNA/ASOs using bioconjugation technologies.
- Support high-throughput and mid-scale oligonucleotide synthesis, including evaluating novel chemistries, modifications, and workflow innovations.
- Develop, refine, and troubleshoot oligonucleotide synthesis, bioconjugation, purification, and analytical methods.
- Use analytical technologies (UV–Vis spectrophotometry, HPLC, mass spectrometry, MALS, and other techniques) to analyze, purify, quantify, and characterize oligonucleotides and bioconjugates.
- Interpret in vitro and in vivo data to generate structure-activity relationships (SAR) to guide iterative experimentation and preclinical candidate nomination.
- Collaborate with cross-functional teams (Biology, Protein Sciences, DMPK) to advance drug discovery objectives.
- Maintain accurate experimental documentation in electronic lab notebooks.
- Communicate results and recommendations in team and cross-functional meetings.
Qualifications/Skills
- 2+ years related experience with a Bachelor’s degree, or 1+ years with a Master’s degree.
- Hands-on experience in oligonucleotide synthesis, purification, and characterization (siRNA/ASOs).
- Experience with bioconjugation chemistry and analytical characterization of oligonucleotide conjugates.
- Ability to develop/troubleshoot workflows and independently design, execute, and interpret experiments.
- Excellent written and verbal communication skills; collaborative, multidisciplinary mindset.
Benefits (if listed)
- Competitive total rewards package including 401k, healthcare coverage, and ESPP.
Application Instructions
- Learn more at https://www.denalitherapeutics.com/careers