Associate Scientist, Oligonucleotide Chemistry & Delivery
Denali Therapeutics
4 months ago
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development
Key Accountabilities / Core Job Responsibilities
- Design, synthesize, purify, and characterize oligonucleotide therapeutics, including siRNA/ASOs, for early discovery OTV programs.
- Design and generate antibody-oligonucleotide conjugates for targeted delivery of siRNA/ASOs using established and emerging bioconjugation technologies.
- Support high-throughput and mid-scale oligonucleotide synthesis, including evaluation of novel chemistries, modifications, and workflow innovations for rapid discovery-stage generation of siRNA/ASOs and bioconjugates.
- Develop, refine, and troubleshoot oligonucleotide synthesis, bioconjugation, purification, and analytical methods for new biotherapeutic designs.
- Use analytical technologies (UV–Vis spectrophotometry, HPLC, mass spectrometry, MALS, and other orthogonal methods) to analyze, purify, quantify, and characterize oligonucleotides and bioconjugates.
- Interpret in vitro and in vivo data to generate structure-activity relationships (SAR) and advance preclinical candidate nomination.
- Collaborate with cross-functional teams (Biology, Protein Sciences, DMPK, and related functions) to advance drug discovery objectives.
- Maintain accurate, complete, and timely electronic laboratory notebook documentation.
- Communicate results, insights, and recommendations clearly in team meetings and cross-functional discussions.
Qualifications / Skills
- Typically requires 2+ years related experience with a Bachelor’s degree; or 1+ years with a Master’s degree.
- Strong hands-on experience with oligonucleotide synthesis, purification, and characterization (siRNA/ASOs).
- Experience with bioconjugation chemistry and analytical characterization of oligonucleotide conjugates.
- Demonstrated ability to develop/troubleshoot workflows and independently design, execute, and interpret experiments in discovery research.
- Excellent written and verbal communication skills; effective in collaborative, multidisciplinary teams.
Benefits / Compensation
- Salary range: $106,000.00 to $138,000.00.
- Competitive total rewards package including 401k, healthcare coverage, ESPP, and other benefits.
Application Instructions
- Learn more at https://www.denalitherapeutics.com/careers
- Design, synthesize, purify, and characterize oligonucleotide therapeutics, including siRNA/ASOs, for early discovery OTV programs.
- Design and generate antibody-oligonucleotide conjugates for targeted delivery of siRNA/ASOs using established and emerging bioconjugation technologies.
- Support high-throughput and mid-scale oligonucleotide synthesis, including evaluation of novel chemistries, modifications, and workflow innovations for rapid discovery-stage generation of siRNA/ASOs and bioconjugates.
- Develop, refine, and troubleshoot oligonucleotide synthesis, bioconjugation, purification, and analytical methods for new biotherapeutic designs.
- Use analytical technologies (UV–Vis spectrophotometry, HPLC, mass spectrometry, MALS, and other orthogonal methods) to analyze, purify, quantify, and characterize oligonucleotides and bioconjugates.
- Interpret in vitro and in vivo data to generate structure-activity relationships (SAR) and advance preclinical candidate nomination.
- Collaborate with cross-functional teams (Biology, Protein Sciences, DMPK, and related functions) to advance drug discovery objectives.
- Maintain accurate, complete, and timely electronic laboratory notebook documentation.
- Communicate results, insights, and recommendations clearly in team meetings and cross-functional discussions.
Qualifications / Skills
- Typically requires 2+ years related experience with a Bachelor’s degree; or 1+ years with a Master’s degree.
- Strong hands-on experience with oligonucleotide synthesis, purification, and characterization (siRNA/ASOs).
- Experience with bioconjugation chemistry and analytical characterization of oligonucleotide conjugates.
- Demonstrated ability to develop/troubleshoot workflows and independently design, execute, and interpret experiments in discovery research.
- Excellent written and verbal communication skills; effective in collaborative, multidisciplinary teams.
Benefits / Compensation
- Salary range: $106,000.00 to $138,000.00.
- Competitive total rewards package including 401k, healthcare coverage, ESPP, and other benefits.
Application Instructions
- Learn more at https://www.denalitherapeutics.com/careers