Associate Scientist II, Conjugation Chemistry

Role Summary

Associate Scientist II, Conjugation Chemistry. We are seeking an independent, goal-oriented candidate to join our protein sciences team and contribute to protein production and conjugation efforts. The role requires a background in protein expression, purification, protein conjugation, and analytical techniques, with ability to work across multiple projects in a fast-paced environment. The successful candidate will collaborate with cross-functional teams across biology, chemistry, and pharmacology to advance research across therapeutic modalities. This lab-based position is onsite in Cambridge, MA (675 W. Kendall St, Cambridge, MA 02142).

Responsibilities

• Work closely with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales.
• Design, plan, and perform protein conjugation experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members.
• Utilize UV–Vis spectroscopy and HPLC to analyze, purify, quantify, characterize, and formulate protein conjugates.
• Contribute to the maintenance of laboratory infrastructure and equipment.
• Support group organization, productivity, and expertise through collaboration and idea exchange.
• Meet quality, quantity, and timeline expectations for all assigned projects.
• Support discovery efforts in protein sciences.
• Maintain accurate and complete electronic notebook records.
• Communicate experimental plans and data to multiple cross-functional scientific teams.

Qualifications

• 0–1 years of relevant laboratory experience in a biopharma or academic setting.
• Experience with modern bioconjugation chemistry and analytical techniques.
• Experience with instrumentation such as Agilent and ÄKTA HPLC systems, TFF, and UV–Vis spectrometry.
• Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, RP-HPLC, HIC, IEX, SDS-PAGE, UV–Vis spectroscopy) and label-free binding techniques (SPR and/or BLI) preferred.
• Experience developing new chromatographic methods is a plus.
• Knowledge of protein purification using ÄKTA systems preferred.
• Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems.
• Detail-oriented, self-motivated, and comfortable working on highly technical projects in a multidisciplinary team setting.

Skills

• Ability to work effectively in a multidisciplinary team.

Education

• BS/MS degree in biology, biochemistry, biophysics, chemistry, or a related field.